FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\elgiUAS.Tag:HA
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General Information
Symbol
Dmel\elgiUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0267933
Feature type
allele
Associated gene
Dmel\elgi
Associated Insertion(s)
Carried in Construct
P{UAS-elgi.T}
Key Links
Transgenic product class
wild_type
(Tan et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tan et al., 2011)
Mutagen
in vitro construct
(Tan et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-elgi.T}
Cytology
Description

UAS regulatory sequences drive expression of wild-type elgi which is tagged at the C-terminal end with Tag:HA.

(Tan et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
elgi
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  neurodegenerative disease
      CEA
      (Tan et al., 2011)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  neurodegenerative disease
      is ameliorated by Hsap\PRKNUAS.cYa
      (Tan et al., 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Nrdp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Ddc.PL results in a significant decrease in the number of dopaminergic (DA) neurons in the dorsomedial clusters of the adult brain. This defect is seen as early as 2 days after eclosion.

      Flies expressing Nrdp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Ddc.PL have reduced flight ability compared to controls.

      (Tan et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The loss of dopaminergic neurons of the adult brain and defects in flight ability caused by expression of Nrdp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Ddc.PL are partially suppressed by co-expression of Hsap\PARK2Scer\UAS.cYa.

      (Tan et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Nrdp1Scer\UAS.T:Ivir\HA1
      elgiScer\UAS.T:Ivir\HA1
      elgiUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)