FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Gr47a1
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General Information
Symbol
Dmel\Gr47a1
Species
D. melanogaster
Name
FlyBase ID
FBal0268065
Feature type
allele
Associated gene
Dmel\Gr47a
Associated Insertion(s)
TI{TI}Gr47a1
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Lee et al., 2015)
Progenitor genotype
Associated Insertion(s)
TI{TI}Gr47a1
Cytology
Description

Residues -166 to +291 of Gr47a have been replaced by mini-w.

(Lee et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Gr47a1 mutant flies do not show significant changes in the expected avoidance response to food laced with acetic acid (5%), as compared to controls.

      (Rimal et al., 2019)

      Gr47a1 mutant flies do not exhibit the normal preference for sucrose over strychnine seen in control flies. Action potentials recorded from the S6 sensilla are abnormal in response to strychnine, but are normal in response to many other bitter compounds. Reduced frequencies are also recorded at two other sensilla that are robustly activated in response to strychnine, (S5, S9 and S10). The response to caffeine in the S12, I9 and I10 sensilla is normal.

      Gr47a1/Df(2R)12 mutant flies do not exhibit the normal preference for sucrose over strychnine seen in control flies.

      The reduction in proboscis extension response (PER) following the application of strychnine seen in wild type flies is severely impaired in Gr47a1 mutant flies. As in wild type flies, robust PERs are seen in response to sucrose.

      (Lee et al., 2015)

      Gr47a1 mutant adults show normal avoidance of umbelliferone in a two-way choice feeding assay.

      (Poudel et al., 2015)

      Mutant flies show normal L-canavanine avoidance in a two-way choice test.

      (Lee et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Gr47a1 is rescued by Gr47a+tCH322-152A22

      (Lee et al., 2015)

      Gr47a1 is rescued by Gr47aUAS.cLa/Scer\GAL4Gr36a.6

      (Lee et al., 2015)

      Gr47a1 is rescued by Gr47aUAS.cLa/Scer\GAL4Gr39b.4.4

      (Lee et al., 2015)

      Gr47a1 is rescued by Gr47aUAS.cLa/Scer\GAL4Gr8a.0.7

      (Lee et al., 2015)
      Not rescued by

      Gr47a1 is not rescued by Gr47aUAS.cLa/Scer\GAL4Gr47a.7.321

      (Lee et al., 2015)

      Gr47a1 is not rescued by Gr47aUAS.cLa/Scer\GAL4Gr59c.5.5

      (Lee et al., 2015)

      Gr47a1 is not rescued by Gr47aUAS.cLa/Scer\GAL4Gr93a.5

      (Lee et al., 2015)

      Gr47a1 is not rescued by Gr47aUAS.cLa/Scer\GAL4Gr98b.8.9

      (Lee et al., 2015)
      Comments

      Expression of Gr47a+tCH322-152A22 rescues the impairment in avoiding strychnine seen in Gr47a1 mutant flies. The reduced action potential frequency recorded at the S6 sensilla in response to strychnine is also rescued.

      Expression of Gr47aScer\UAS.cLa under the control of Scer\GAL4Gr47a.7.321 does not rescue the impairment in avoiding strychnine seen in Gr47a1 mutant flies.

      Expression of Gr47aScer\UAS.cLa under the control of Scer\GAL4Gr36a.6, Scer\GAL4Gr39b.4.4 or Scer\GAL4Gr8a.0.7 rescues the impairment in strychnine avoidance seen in Gr47a1 mutant flies. No rescue is seen with Scer\GAL4Gr59c.5.5, Scer\GAL4Gr93a.5 or Scer\GAL4Gr98b.8.9. The loss of strychnine-induced action potentials in S6 is rescued when Gr47aScer\UAS.cLa is expressed under the control of Scer\GAL4Gr59c.5.5 or Scer\GAL4Gr98b.8.9, but not with Scer\GAL4Gr93a.5.

      Expression of Gr47aScer\UAS.cLa under the control of Scer\GAL4Gr36a.6 rescues the proboscis extension response defects seen in Gr47a1 mutant flies upon application of strychnine.

      (Lee et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (12)