FB2026_03 , released September 17, 2026
Allele: Dmel\mbl398
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General Information
Symbol
Dmel\mbl398
Species
D. melanogaster
Name
FlyBase ID
FBal0268268
Feature type
allele
Associated gene
Dmel\mbl
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Irion, 2012)
Progenitor genotype
P{SUPor-P}mblKG08885
(Irion, 2012)
P{EPgy2}EY22804
(Irion, 2012)
Cytology
Description

A deletion resulting from the simultaneous mobilisation of P{EPgy2}EY22804 and P{SUPor-P}mblKG08885 that removes almost the complete mbl coding sequence leaving only exons 1 and 2 intact. The remaining sequence encodes for the first 64 amino acids of the wild-type protein.

(Irion, 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mbl398 and hemizygous mbl398/Df(2R)BSC154 animals die as embryos. Both homo- and hemizygous embryos show a hyper-contracted abdomen.

      (Irion, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      mbl398 is partially rescued by mblUAS.804aa

      (Irion, 2012)

      mbl398 is partially rescued by mblUAS.847aa

      (Irion, 2012)

      mbl398 is partially rescued by mblUAS.848aa

      (Irion, 2012)

      mbl398 is partially rescued by mblUAS.925aa

      (Irion, 2012)

      mbl398 is partially rescued by mblUAS.940aa

      (Irion, 2012)
      Comments

      Expression of mblScer\UAS.940aa under the control of Scer\GAL4da.G32 rescues the embryonic lethality of mbl398, but the transgene fails to restore adult viability.

      Expression of mblScer\UAS.925aa under the control of Scer\GAL4da.G32 rescues the embryonic lethality of mbl398, but the transgene fails to restore adult viability.

      Expression of mblScer\UAS.848aa under the control of Scer\GAL4da.G32 rescues the embryonic lethality of mbl398, but the transgene fails to restore adult viability.

      Expression of mblScer\UAS.847aa under the control of Scer\GAL4da.G32 rescues the embryonic lethality of mbl398, but the transgene fails to restore adult viability.

      Expression of mblScer\UAS.804aa under the control of Scer\GAL4da.G32 rescues the embryonic lethality of mbl398, but the transgene fails to restore adult viability.

      (Irion, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mbl39/8
      (Irion, 2012)
      mbl398
      Name Synonyms
      Secondary FlyBase IDs
        References (1)