FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\prosIG2227
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General Information
Symbol
Dmel\prosIG2227
Species
D. melanogaster
Name
FlyBase ID
FBal0268589
Feature type
allele
Associated gene
Dmel\pros
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hartl et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: L850R.

(Hartl et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:11,375,638..11,375,638 [+]
Nucleotide change:

T11375638G

Amino acid change:

L1150R | pros-PH; L1150R | pros-PI; L850R | pros-PJ; L850R | pros-PK; L850R | pros-PL; L1150R | pros-PM

Reported amino acid change:

L850R

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Note: the mutation was annotated at residue L850 of isoforms pros-PJ, PK, PL, and PM, (r5.54) as this was deemed the more likely site of the mutation. There is also an L850 codon in isoforms pros-LH and LI, which could also be the site of the mutation. The mutation was reported only as L850R.

(Hartl et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones induced by the eyFLP method result in ectopic CO[[2]] neurons on the maxillary palp (MP). The ectopic neurons show dual targeting specificity: in addition to targeting the V-glomerulus they also innervate a set of medial glomeruli normally innervated by two MP olfactory receptor neuron classes. The ectopic neurons are functional and respond to CO[[2]]. The number of antennal CO[[2]] neurons is unaffected.

      (Hartl et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of mir-279Scer\UAS.T:Disc\RFP under the control of Scer\GAL4Act.PU suppresses the formation of ectopic CO[[2]] neurons on the maxillary palp caused by prosIG2227 clones in 80% of animals.

      The number of ectopic CO[[2]] neurons on the maxillary palp in animals containing prosIG2227 clones is significantly suppressed if they are also carrying either esgk00606/+ or nerfin-1159/+, but is unaffected if they are also carrying exexKK30/+.

      (Hartl et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      prosIG2227 is rescued by Scer\GAL4Act.PU/prosUAS.cMa

      (Hartl et al., 2011)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      prosIG2227
      (Hartl et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)