Larvae expressing prosScer\UAS.cMa under the control of prosScer\UAS.cMa (using heat shock) show a marked decrease in the number of mitotically active cells in the brain compared to controls. This reduction is seen both in the outer proliferation centre and in the central brain.
Expression of prosUAS.cMa under the control of Scer\GAL4GMR19H09 does not cause type II to type I neuroblast transformation, but does cause loss of type II neuroblasts and reduction in the number of intermediate progenitors and neurons generated by type II neuroblasts at 120 hours after larval hatching. Expression of prosUAS.cMa under the control of Scer\GAL4GMR9D11 does not cause loss of type II neuroblasts, but does cause a large reduction in the number of intermediate progenitors and neurons generated by type II neuroblasts at 96 hours and 120 hours after larval hatching.
When prosScer\UAS.cMa is driven by Scer\GAL4sca-P309, a striking reduction in external structures on the adult antenna is seen. No increase in the number of glia or neurons is seen.
Expression of prosScer\UAS.cMa under the control of Scer\GAL4Kr.PM in embryos results in thinning and disruptions in the ventral nerve cord, and reduced epidermal and mesodermal structures. There is a strong reduction in BrdU labeling in these embryos compared to wild type.
Animals expressing prosScer\UAS.cMa under the control of Scer\GAL4sca-109-68 die as pharate adults and are virtually bald, having less than 1% of the normal external sense organ bristles in the notum and eye. The external sense organs lack both the bristle and socket.