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General Information
Symbol
Dmel\prosUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Matsuzaki
FlyBase ID
FBal0096724
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-pros
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of full length pros.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  brain cancer
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

interommatidial bristle & tormogen cell, with Scer\GAL4sca-109-68

interommatidial bristle & trichogen cell, with Scer\GAL4sca-109-68

microchaeta & antennal segment 3, with Scer\GAL4sca-P309

scutum & external sensory organ & tormogen cell, with Scer\GAL4sca-P309

scutum & external sensory organ & trichogen cell, with Scer\GAL4sca-P309

scutum & macrochaeta, with Scer\GAL4sca-109-68

scutum & macrochaeta & tormogen cell, with Scer\GAL4sca-109-68

scutum & macrochaeta & trichogen cell, with Scer\GAL4sca-109-68

scutum & microchaeta, with Scer\GAL4sca-109-68

scutum & microchaeta & tormogen cell, with Scer\GAL4sca-109-68

scutum & microchaeta & trichogen cell, with Scer\GAL4sca-109-68

Detailed Description
Statement
Reference

Larvae expressing prosScer\UAS.cMa under the control of prosScer\UAS.cMa (using heat shock) show a marked decrease in the number of mitotically active cells in the brain compared to controls. This reduction is seen both in the outer proliferation centre and in the central brain.

Expression of prosUAS.cMa under the control of Scer\GAL4GMR19H09 does not cause type II to type I neuroblast transformation, but does cause loss of type II neuroblasts and reduction in the number of intermediate progenitors and neurons generated by type II neuroblasts at 120 hours after larval hatching. Expression of prosUAS.cMa under the control of Scer\GAL4GMR9D11 does not cause loss of type II neuroblasts, but does cause a large reduction in the number of intermediate progenitors and neurons generated by type II neuroblasts at 96 hours and 120 hours after larval hatching.

Expression of prosScer\UAS.cMa in the neuroblasts under the control of Scer\GAL4wor.PA results in depletion of larval neuroblast numbers.

Ectopic expression of prosScer\UAS.cMa, under the control of Scer\GAL4en-e16E causes a precocious stop in cell division within the NB7-3 lineage.

When prosScer\UAS.cMa is driven by Scer\GAL4sca-P309, a striking reduction in external structures on the adult antenna is seen. No increase in the number of glia or neurons is seen.

Expression of prosScer\UAS.cMa under the control of Scer\GAL4dpp.blk1 inhibits furrow reincarnation in the eye disc.

When prosScer\UAS.cMa is driven by Scer\GAL4eg-Mz360 or Scer\GAL4sca-4512 no increase in NGB6-4t-derived glial cells is seen.

Expression of prosScer\UAS.cMa under the control of Scer\GAL4Kr.PM in embryos results in thinning and disruptions in the ventral nerve cord, and reduced epidermal and mesodermal structures. There is a strong reduction in BrdU labeling in these embryos compared to wild type.

Animals expressing prosScer\UAS.cMa under the control of Scer\GAL4sca-109-68 die as pharate adults and are virtually bald, having less than 1% of the normal external sense organ bristles in the notum and eye. The external sense organs lack both the bristle and socket.

Flies expressing prosScer\UAS.cMa under the control of Scer\GAL4sca-P309 have a bald notum where both the shaft and socket of the bristles are absent.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of prosScer\UAS.cMa under the control of Scer\GAL4Act.PU suppresses the formation of ectopic CO[[2]] neurons on the maxillary palp caused by mir-279S096207 clones in 37% of animals.

Co-overexpression of prosScer\UAS.cMa and tllScer\UAS.cKa by Scer\GAL4elav.Switch.PO rescues the tllScer\UAS.cKa-induced brain hyperplasia in third instar larvae.

Expression of prosScer\UAS.cMa, under the control of Scer\GAL4αTub84B.PL, in brat11 mutant larval clones significantly suppresses the overproliferation phenotype in these clones in the central larval brain. Over 90% of Scer\GAL4αTub84B.PL>prosScer\UAS.cMa, brat11 clones in the central brain have <100 cells, while over 80% of brat11 clones have 200-1000 cells.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
prosScer\UAS.cMa
prosUAS.cMa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Matsuzaki
Secondary FlyBase IDs
    References (19)