FlyBase Allele Report: Dmel\InR[3T5]

General Information

Symbol

Dmel\InR^3T5

Species

D. melanogaster

Name

FlyBase ID

FBal0268608

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of type 2 diabetes mellitus

CEA with InR^E19

(Murillo-Maldonado et al., 2011)

CEA with InR⁰⁵⁵⁴⁵

(Murillo-Maldonado et al., 2011)

model of glucose metabolism disease

CEA with InR^E19

(Álvarez-Rendón and Riesgo-Escovar, 2023, Álvarez-Rendón and Riesgo-Escovar, 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | adult stage (with InR^E19)

(Murillo-Maldonado et al., 2011)

decreased body size | adult stage (with InR⁰⁵⁵⁴⁵)

(Murillo-Maldonado et al., 2011)

decreased body size | adult stage (with InR^E19)

(Murillo-Maldonado et al., 2011)

increased rate of adult locomotory behavior (with InR^E19)

(Álvarez-Rendón and Riesgo-Escovar, 2023)

viable (with InR⁰⁵⁵⁴⁵)

(Murillo-Maldonado et al., 2011)

viable (with InR^E19)

(Murillo-Maldonado et al., 2011)

visible | adult stage (with InR⁰⁵⁵⁴⁵)

(Murillo-Maldonado et al., 2011)

visible | adult stage (with InR^E19)

(Murillo-Maldonado et al., 2011)

Phenotype Manifest In

wing (with InR⁰⁵⁵⁴⁵)

(Murillo-Maldonado et al., 2011)

wing (with InR^E19)

(Murillo-Maldonado et al., 2011)

wing vein | ectopic (with InR^E19)

(Murillo-Maldonado et al., 2011)

Detailed Description

Statement

Reference

InR⁰⁵⁵⁴⁵/InR^3T5 mutant adult flies have a reduced body weight compared to heterozygous controls. Wing area is also reduced compared to controls.

Lipid content is increased in InR⁰⁵⁵⁴⁵/InR^3T5 mutant flies compared to controls. Carbohydrate content is similar to controls.

InR⁰⁵⁵⁴⁵/InR^3T5 mutant flies exhibit normal electroretinogram (ERG) readings.

InR^3T5/InR^E19 mutant adult flies have a reduced body weight compared to heterozygous controls. Wing area is also reduced compared to controls.

Lipid and carbohydrate content are increased in InR^3T5/InR^E19 mutant flies compared to controls.

InR^3T5/InR^E19 mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is not significantly reduced in InR^3T5/InR^E19 mutant flies compared to controls.

(Murillo-Maldonado et al., 2011)

12.7% of InR^3T5/InR^E19 mutant wings show small ectopic vein-like patches. No ectopic wing vein is seen in either heterozygote.

(Murillo-Maldonado et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

InR^E19/InR^3T5 has increased rate of adult locomotory behavior phenotype, non-enhanceable by Keap1^EY02632

(Álvarez-Rendón and Riesgo-Escovar, 2023)

NOT suppressed by

Statement

Reference

InR^E19/InR^3T5 has increased rate of adult locomotory behavior phenotype, non-suppressible by Keap1^EY02632

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Other

Statement

Reference

InR^E19/InR^3T5, Keap1^EY02632 has chemical resistant | adult stage phenotype

(Álvarez-Rendón and Riesgo-Escovar, 2023)

InR^E19/InR^3T5, Keap1^EY02632 has abnormal oxidative stress response | adult stage phenotype

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

InR^3T5

(Murillo-Maldonado et al., 2011, Murillo-Maldonado et al., 2011)

InR^3t5

(Álvarez-Rendón and Riesgo-Escovar, 2023, Álvarez-Rendón and Riesgo-Escovar, 2020)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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