FlyBase Allele Report: Dmel\Keap1[EY02632]

General Information

Symbol

Dmel\Keap1^EY02632

Species

D. melanogaster

Name

FlyBase ID

FBal0217113

Feature type

allele

Associated gene

Dmel\Keap1

Associated Insertion(s)

P{EPgy2}Keap1^EY02632

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Keap1^EY02632

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:17,078,122..17,078,122 [-]

(Chatterjee et al., 2022, Nagy et al., 2013, FlyBase Curators, 2008-, Sykiotis and Bohmann, 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates cancer

modeled by l(2)gl^HMS01905

(Chatterjee et al., 2022)

ameliorates glucose metabolism disease

modeled by InR^3T5, InR^E19

(Álvarez-Rendón and Riesgo-Escovar, 2023)

modeled by S6k⁰⁷⁰⁸⁴, S6k^l-1

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal adult locomotory behavior

(Álvarez-Rendón and Riesgo-Escovar, 2023)

abnormal oxidative stress response | adult stage

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Keap1^EY02632 is a non-enhancer of increased rate of adult locomotory behavior phenotype of InR^E19/InR^3T5

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Suppressor of

Statement

Reference

Keap1^EY02632, Scer\GAL4^unspecified is a suppressor of increased cell growth rate | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified

(Nagy et al., 2013)

Keap1^EY02632, Scer\GAL4^unspecified is a suppressor of increased cell growth rate | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified, ref(2)P^HMS00938

(Nagy et al., 2013)

NOT Suppressor of

Statement

Reference

Keap1^EY02632 is a non-suppressor of increased rate of adult locomotory behavior phenotype of InR^E19/InR^3T5

(Álvarez-Rendón and Riesgo-Escovar, 2023)

Other

Statement

Reference

Phenotype Manifest In

Suppressor of

Statement

Reference

Keap1^EY02632, Scer\GAL4^unspecified is a suppressor of embryonic/larval fat body | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified

(Nagy et al., 2013)

Keap1^EY02632, Scer\GAL4^unspecified is a suppressor of embryonic/larval fat body | somatic clone | third instar larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^unspecified, ref(2)P^HMS00938

(Nagy et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

15427

y¹ w^67c23; P{EPgy2}Keap1^EY02632

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Keap1^EY02632

(Álvarez-Rendón and Riesgo-Escovar, 2023)

UAS-Keap1[/2, EY15427]

(Nagy et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections