FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ref(2)PHMS00938
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General Information
Symbol
Dmel\ref(2)PHMS00938
Species
D. melanogaster
Name
FlyBase ID
FBal0257608
Feature type
allele
Associated gene
Dmel\ref(2)P
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS00938}
Also Known As
UAS-ref(2)P RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS00938}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS00938
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of ref(2)PHMS00938 under the control of Scer\GAL4Cg.PA does not affect the number of autophagosome-like structures (Atg8a-positive) in the early third instar larval fat body, as compared to controls.

      The expression of ref(2)PHMS00938 under the control of Scer\GAL4GMR.PU (together with Dicer-2, for efficient RNAi) leads to mild photoreceptor degeneration (i.e. loss of rhabdomeres), as compared to controls.

      (Liu et al., 2018)

      Expression of ref(2)PHMS00938 under the control of Scer\GAL4Myo31DF-NP0001 does not lead to any defects in midgut degradation after pupariation, with no significant difference in the size of the gastric caeca 4 hrs after puparium formation, or in autophagy levels 2 hrs after puparium formation.

      (Xu et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      ref(2)PHMS00938, Scer\GAL4GMR.PU is a non-enhancer of eye phenotype of Chchd2S81L.UAS, Scer\GAL4GMR.PU

      (Baek et al., 2021)
      Suppressor of
      Statement
      Reference

      ref(2)PHMS00938, Scer\GAL4ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Atg8aHMS06041, Scer\GAL4ppk.PU

      (Tan et al., 2024)

      ref(2)PHMS00938, Scer\GAL4ppk.PU is a suppressor | partially of dendrite | P-stage phenotype of Atg8aHMS06041, Scer\GAL4ppk.PU

      (Tan et al., 2024)

      ref(2)PHMS00938, Scer\GAL4ppk.PU is a suppressor | partially of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Atg1HMS02750, Scer\GAL4ppk.PU

      (Tan et al., 2024)

      ref(2)PHMS00938, Scer\GAL4ppk.PU is a suppressor | partially of dendrite | P-stage phenotype of Atg1HMS02750, Scer\GAL4ppk.PU

      (Tan et al., 2024)

      Scer\GAL4ppk.PU/ref(2)PHMS00938 is a suppressor of larval dorsal multidendritic neuron ddaC | P-stage phenotype of Scer\GAL4ppk.PU, cncGD4437

      (Tan et al., 2024)

      Scer\GAL4ppk.PU/ref(2)PHMS00938 is a suppressor of dendrite | P-stage phenotype of Scer\GAL4ppk.PU, cncGD4437

      (Tan et al., 2024)

      Scer\GAL4Cg.PA/ref(2)PHMS00938 is a suppressor | partially of fat cell | early third instar larval stage phenotype of Scer\GAL4Cg.PA, Tom40JF02030

      (Liu et al., 2018)

      Scer\GAL4Cg.PA/ref(2)PHMS00938 is a suppressor | partially of autophagosome | early third instar larval stage phenotype of Scer\GAL4Cg.PA, Tom40JF02030

      (Liu et al., 2018)

      ref(2)PHMS00938/Scer\GAL4GMR.PU is a suppressor | partially of rhabdomere of eye photoreceptor cell | adult stage | progressive phenotype of Scer\GAL4GMR.PU, Tom40JF02030

      (Liu et al., 2018)

      ref(2)PHMS00938, Scer\GAL4unspecified is a suppressor of embryonic/larval fat body | somatic clone | third instar larval stage phenotype of MycUAS.cZa, Scer\GAL4unspecified

      (Nagy et al., 2013)
      NOT Suppressor of
      Statement
      Reference

      ref(2)PHMS00938, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of Chchd2S81L.UAS, Scer\GAL4GMR.PU

      (Baek et al., 2021)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      p62[i3, HMS00938]
      (Nagy et al., 2013)
      ref(2)P/p62RNAi-2
      (Zhao et al., 2023)
      ref(2)PHMS00938
      Name Synonyms
      Secondary FlyBase IDs
        References (17)