FlyBase Allele Report: Dmel\pnr[SA.UAS.β]

General Information

Symbol

Dmel\pnr^SA.UAS.β

Species

D. melanogaster

Name

FlyBase ID

FBal0268845

Feature type

allele

Associated gene

Dmel\pnr

Associated Insertion(s)

Carried in Construct

P{UAS-pnr.β.SA}

Key Links

Transgenic product class

missense_variant

(Yang et al., 2012)

polypeptide_post_translational_processing_variant

(Yang et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Yang et al., 2012)

polypeptide_post_translational_processing_variant

(Yang et al., 2012)

Mutagen

in vitro construct

(Yang et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-pnr.β.SA}

Cytology

Description

UAS regulatory sequences drive expression of a mutated pnr-β isoform in which the two potential phosphorylation sites (S101 and S391) have been mutated to Ala.

(Yang et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

pnr

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^C-765

(Yang et al., 2012)

Phenotype Manifest In

macrochaeta | ectopic, with Scer\GAL4^C-765

(Yang et al., 2012)

Detailed Description

Statement

Reference

Expression of pnr^{SA.Scer\UAS.β} under the control of Scer\GAL4^C-765 results in additional macrochaetae on the notum (flies have an average of 19 extra macrochaetae per thorax).

(Yang et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

pnr^SA.UAS.β/Scer\GAL4^pnr-MD237 is a suppressor of visible phenotype of wg^Sp-1/wg^l-17

(Yang et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

pnr^SA.UAS.β/Scer\GAL4^pnr-MD237 is a suppressor of dorsocentral bristle phenotype of wg^Sp-1/wg^l-17

(Yang et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of pnr^{SA.Scer\UAS.β} under the control of Scer\GAL4^pnr-MD237 results in greater rescue of the loss of dorsocentral bristles seen in wg^Sp-1/wg^l-17 flies than expression of pnr^Scer\UAS.β under the control of Scer\GAL4^pnr-MD237.

(Yang et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

pnr^SA.UAS.β/Scer\GAL4^pnr-MD237 rescues pnr^MD237/pnr^VX6

(Yang et al., 2012)

Comments

Expression of pnr^{SA.Scer\UAS.β} under the control of Scer\GAL4^pnr-MD237 results in significant rescue (4.6 bristles per thorax) of the loss of dorsocentral bristles seen in pnr^VX6/pnr^MD237 flies.

(Yang et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pnr^{SA.Scer\UAS.β}

pnr^SA.UAS.β

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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