FlyBase Allele Report: Dmel\wg[Sp-1]

General Information

Symbol

Dmel\wg^Sp-1

Species

D. melanogaster

Name

Sternopleural

FlyBase ID

FBal0015984

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

Also Known As

Key Links

Allele class

loss of function allele

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Buratovich et al., 1997)

loss of function allele

(Buratovich et al., 1997)

Mutagen

spontaneous

ethyl methanesulfonate

(Tiong and Nash, 1990)

Progenitor genotype

Cytology

Polytene chromosomes apparently normal (Morgan, Bridges and Schultz, 1937).

Description

Mutation in the 3' regulatory region of wg.

(Neumann and Cohen, 1997)

Regulatory mutation.

(Neumann and Cohen, 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal tergite 8 | female (with wg^l-16)

(Gorfinkiel et al., 2003)

aedeagus (with wg^l-16)

(Gorfinkiel et al., 2003)

anterior dorsocentral bristle

(Tomoyasu et al., 1998, Buratovich et al., 1997)

anterior dorsocentral bristle (with wg^l-17)

(Yang et al., 2012)

epandrial ventral lobe (with wg^l-16)

(Gorfinkiel et al., 2003)

hypogynium (with wg^l-16)

(Gorfinkiel et al., 2003)

mesothoracic leg disc

(Neumann and Cohen, 1996)

oviprovector (with wg^l-16)

(Gorfinkiel et al., 2003)

sternopleural bristle

(Buratovich et al., 1997)

surstylus (with wg^l-16)

(Gorfinkiel et al., 2003)

wing

(Buratovich et al., 1997)

wing disc

(Neumann and Cohen, 1996)

Detailed Description

Statement

Reference

The anterior dorsocentral bristle is missing in 61% of wg^Sp-1/wg^l-17 flies. When present, it is 14% shorter than normal.

(Yang et al., 2012)

wg^l-16/wg^Sp-1 females have reduced vaginal plates and tergite eight and the vulva is mainly absent. wg^l-16/wg^Sp-1 males lack the penis apparatus and most of the clasper, and the lateral plates are fused.

(Gorfinkiel et al., 2003)

wg^l-12/wg^Sp-1 flies lack the anterior dorsocentral bristle.

(Tomoyasu et al., 1998)

A rearrangement and increase in the number of large bristles on the sternopleurite. When in combination with wg^spd-fg homozygotes the level of wing etching is increased (compared to wg^spd-fg homozygotes). When in combination with other null or hypomorphic alleles the mutants are viable. Transheterozygotes lose one or both of the anterior dorsocentral macrochaetes. Transheterozygotes with wg^Sp-1 exhibit occasional etching of the wing margin and hold their wings in an abnormal out-stretched position.

(Buratovich et al., 1997)

Homozygous second leg imaginal dics exhibit a severe overgrowth on the dorsal side causing additional folds. wg^P/wg^Sp-1 and wg^l-16/wg^Sp-1 individuals are lethal. Adult escapers from this cross lack one or both anterior dorsocentral bristles and more rarely also the posterior postalar bristle and the presutural bristle. They also exhibit loss of distal antennal segments and in rare cases exhibit antennal duplication. wg^l-17/wg^Sp-1 flies are viable and exhibit loss of anterior dorsocentrals and loss of microbristles located in the wg-expression domain of the notum. wg^l-17/wg^Sp-1 flies in addition exhibit loss of distal antennal segments. Individual in combination with wg^Sp-revP are pupal lethal and in combination with wg¹ are wild-type.

(Neumann and Cohen, 1996)

Extra bristles on the sternopleurite.

(Tiong and Nash, 1990)

Sternopleural bristles increased in number. At 19^oC, wild type; at 25^oC, overlaps wild type; at 28^oC-30^oC, no overlap. Apparently does not affect sternopleural bristles on metathoracic segment converted by bx to a mesothoracic segment (Waddington, 1939). RK2. Homozygous lethal.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

wg^Sp-1/wg^l-17 has visible phenotype, suppressible by pnr^SA.UAS.β/Scer\GAL4^pnr-MD237

(Yang et al., 2012)

wg^Sp-1/wg^l-17 has visible phenotype, suppressible by Scer\GAL4^pnr-MD237/sc^SA.UAS

(Yang et al., 2012)

Suppressor of

Statement

Reference

wg^Sp-1/wg[+] is a suppressor | partially of visible phenotype of mir-965^KO1/mir-965^KO2

(Verma and Cohen, 2015)

wg^Sp-1, wg[+], stg⁴, stg[+] is a suppressor | partially of visible phenotype of mir-965^KO1/mir-965^KO2

(Verma and Cohen, 2015)

wg^Sp-1/wg[+] is a suppressor of abnormal size phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

wg^Sp-1/wg[+] is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

wg^Sp-1/wg[+] is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

NOT Suppressor of

Statement

Reference

wg^Sp-1/wg[+] is a non-suppressor | partially of visible phenotype of mir-965^KO1/mir-965^KO2

(Verma and Cohen, 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

wg^Sp-1/wg^l-17 has dorsocentral bristle phenotype, suppressible by pnr^SA.UAS.β/Scer\GAL4^pnr-MD237

(Yang et al., 2012)

wg^Sp-1/wg^l-17 has dorsocentral bristle phenotype, suppressible by Scer\GAL4^pnr-MD237/sc^SA.UAS

(Yang et al., 2012)

NOT suppressed by

Statement

Reference

wg^Sp-1 has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Suppressor of

Statement

Reference

wg^Sp-1/wg[+] is a suppressor | partially of abdomen phenotype of mir-965^KO1/mir-965^KO2

(Verma and Cohen, 2015)

wg^Sp-1, wg[+], stg⁴, stg[+] is a suppressor | partially of abdomen phenotype of mir-965^KO1/mir-965^KO2

(Verma and Cohen, 2015)

wg^Sp-1/wg[+] is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

wg^Sp-1 is a suppressor of macrochaeta | increased number phenotype of Dronc^C318G.UAS, Scer\GAL4^sca-P309

(Kanuka et al., 2005)

NOT Suppressor of

Statement

Reference

wg^Sp-1/wg[+] is a non-suppressor | partially of abdomen phenotype of mir-965^KO1/mir-965^KO2

(Verma and Cohen, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of wg^Sp-1 partially suppresses the segment gap phenotype seen in the abdomens of mir-965^KO1/mir-965^KO2 mutant flies.

One copy each of stg⁴ and wg^Sp-1 partially suppresses the segment gap phenotype seen in the abdomens of mir-965^KO1/mir-965^KO2 mutant flies.

(Verma and Cohen, 2015)

Expression of pnr^{SA.Scer\UAS.β} under the control of Scer\GAL4^pnr-MD237 results in greater rescue of the loss of dorsocentral bristles seen in wg^Sp-1/wg^l-17 flies than expression of pnr^Scer\UAS.β under the control of Scer\GAL4^pnr-MD237.

Expression of sc^SA.Scer\UAS under the control of Scer\GAL4^DC results in greater rescue of the loss of dorsocentral bristles seen in wg^Sp-1/wg^l-17 flies than expression of sc^Scer\UAS.cUa under the control of Scer\GAL4^DC.

(Yang et al., 2012)

The wg^Sp-1 mutation is able to suppress the increase in extra macrochaetae seen when Nc^{C318G.Scer\UAS} is expressed under the control of Scer\GAL4^sca-P309.

(Kanuka et al., 2005)

Flies expressing tkv^{Q199D.Scer\UAS.cTa} under the control of Scer\GAL4^tsh-Gal4-1 in a wg^l-12/wg^Sp-1 background do not have any ectopic dorsocentral bristles, although they have ectopic anterior postalar and posterior supraalar bristles.

(Tomoyasu et al., 1998)

Xenogenetic Interactions

Statement

Reference

wg^Sp-1/+ significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU.

(Dupont et al., 2012)

Complementation and Rescue Data

Partially rescued by

wg^Sp-1/wg^l-16 is partially rescued by wg^UAS.cLa/Scer\GAL4^cad-em459

(Gorfinkiel et al., 2003)

Comments

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^cad-em459 in wg^l-16/wg^Sp-1 females sometimes results in recovery of the vaginal plates and tergite eight, but not the vulva. The analia are much reduced in some cases and some females have no genital and anal structures. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^cad-em459 in wg^l-16/wg^Sp-1 males results in recovery of genital structures such as the claspers and penis apparatus, although the penis apparatus is sometimes still reduced. Analia are almost normal or reduced.

(Gorfinkiel et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (504)

Bloomington

259

chy¹ wg^Sp-1/CyO

605543

wg^Sp-1/CyO; P{GawB}Mz160

405

dpy^ov1 wg^Sp-1/SM5

8379

w¹¹¹⁸; wg^Sp-1/CyO

605353

P{nompA-GAL4.K}15; wg^Sp-1/CyO

56560

w^*; wg^Sp-1/CyO; P{UAS-ey.H}3

7757

w¹¹¹⁸; P{hs-hid}2, wg^Sp-1/CyO

8596

w^*; wg^Sp-1/CyO; P{UAS-Abl.F}3

94928

w^*; wg^Sp-1/CyO; P{GFP-SCAR}30

4407

y¹; wg^Sp-1/SM1; ry⁵⁰⁶

Kyoto

105895

wg^Sp-1/SM5

130385

w¹¹¹⁸; wg^Sp-1 / CyO

More stocks available...

Notes on Origin

Discoverer

M. (Mann) Lesley.

Comments

Loss of function phenotype in the wing, antennae and notal bristles but gain of function phenotype in the legs and aDC bristles (rescues wg loss of function).

(Buratovich et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

(Zhang et al., 2015, Gorfinkiel et al., 2003, Neumann and Cohen, 1997, Tiong and Nash, 1990)

Sp¹

(Buratovich et al., 1997)

wg^SP-1

(Verma and Cohen, 2015, Dupont et al., 2012, Kanuka et al., 2005)

wg^Sp-1

(Titus et al., 2023, Cassidy et al., 2019, Yang et al., 2012, Knox et al., 2011, Christensen and Cook, 2007.5.8, Christensen et al., 2007.10.29, Christensen and Cook, 2006.12.5)

wg^Sp1

(Tomoyasu et al., 1998)

wg^Sp

(Sato et al., 1999)

Name Synonyms

Sternopleural

(Zhang et al., 2015)

Secondary FlyBase IDs

References (27)

Report Sections

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