FlyBase Allele Report: Dmel\chico[UAS.cNa]

General Information

Symbol

Dmel\chico^UAS.cNa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Naganos

FlyBase ID

FBal0268941

Feature type

allele

Associated gene

Dmel\chico

Associated Insertion(s)

Carried in Construct

P{UAS-chico.N}

Also Known As

UAS-chico

Key Links

Transgenic product class

cDNA

(Naganos et al., 2012)

wild_type

(Naganos et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Naganos et al., 2012)

wild_type

(Naganos et al., 2012)

Mutagen

in vitro construct

(Naganos et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-chico.N}

Cytology

Description

UASt regulatory sequences drive expression of a chico cDNA (nucleotides +29 to +3185 relative to the transcription start site).

(Naganos et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

chico

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates type 2 diabetes mellitus

modeled by Uch^KO

(Lee et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/chico^UAS.cNa is a suppressor of decreased cell number | adult stage | progressive phenotype of Uch^KO

(Lee et al., 2024)

Scer\GAL4^VGlut1-OK371/chico^UAS.cNa is a suppressor of abnormal sensory perception | recessive | adult stage | progressive phenotype of Uch^KO

(Lee et al., 2024)

chico^UAS.cNa, Scer\GAL4^VGlut1-OK371 is a suppressor of decreased cell number | adult stage | progressive phenotype of Cul1^{UAS.ORF.Tag:HA}, Scer\GAL4^VGlut1-OK371

(Lee et al., 2024)

chico^UAS.cNa, Scer\GAL4^VGlut1-OK371 is a suppressor of abnormal sensory perception | adult stage | progressive phenotype of Cul1^{UAS.ORF.Tag:HA}, Scer\GAL4^VGlut1-OK371

(Lee et al., 2024)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/chico^UAS.cNa is a suppressor of mechanosensory neuron of leg campaniform sensillum | decreased number phenotype of Uch^KO

(Lee et al., 2024)

Scer\GAL4^VGlut1-OK371/chico^UAS.cNa is a suppressor of axon | adult stage phenotype of Uch^KO

(Lee et al., 2024)

Scer\GAL4^VGlut1-OK371/chico^UAS.cNa is a suppressor of adult hemolymph phenotype of Uch^KO

(Lee et al., 2024)

chico^UAS.cNa, Scer\GAL4^hs.PB is a suppressor of adult hemolymph phenotype of Cul1^{UAS.ORF.Tag:HA}, Scer\GAL4^hs.PB

(Lee et al., 2024)

chico^UAS.cNa, Scer\GAL4^VGlut1-OK371 is a suppressor of mechanosensory neuron of leg campaniform sensillum | decreased number phenotype of Cul1^{UAS.ORF.Tag:HA}, Scer\GAL4^VGlut1-OK371

(Lee et al., 2024)

chico^UAS.cNa, Scer\GAL4^VGlut1-OK371 is a suppressor of axon | adult stage phenotype of Cul1^{UAS.ORF.Tag:HA}, Scer\GAL4^VGlut1-OK371

(Lee et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

chico^UAS.cNa/Scer\GAL4^elav.PLu rescues chico¹

(Naganos et al., 2012)

Scer\GAL4^c309/chico^UAS.cNa rescues chico¹

(Naganos et al., 2012)

Partially rescues

Scer\GAL4^ey-OK107/chico^UAS.cNa partially rescues chico¹

(Naganos et al., 2012)

Fails to rescue

Scer\GAL4^{elav.Switch.PO}/chico^UAS.cNa fails to rescue chico¹

(Naganos et al., 2012)

chico^UAS.cNa/Scer\GAL4^GH146 fails to rescue chico¹

(Naganos et al., 2012)

Comments

Expression of chico^Scer\UAS.cNa under the control of Scer\GAL4^elav.PLu rescues the defects in 1 hour memory seen after olfactory aversive conditioning in chico¹ adults.

Expression of chico^Scer\UAS.cNa limited to the adult stage (driven by Scer\GAL4^{elav.Switch.PO} in the presence of RU486) does not rescue the defects in 1 hour memory seen after olfactory aversive conditioning in chico¹ adults.

Expression of chico^Scer\UAS.cNa under the control of Scer\GAL4^ey-OK107 rescues the number of Kenyon cells and partially rescues reduced mushroom body size in chico¹ adults. Olfactory learning is rescued in these flies.

Expression of chico^Scer\UAS.cNa under the control of Scer\GAL4^c309, but not under the control of Scer\GAL4^GH146, rescues olfactory learning in chico¹ adults.

(Naganos et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

chico^Scer\UAS.cNa

chico^UAS.cNa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Naganos

Secondary FlyBase IDs

References (3)

Report Sections

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