FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Src42ANIG.7873R
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General Information
Symbol
Dmel\Src42ANIG.7873R
Species
D. melanogaster
Name
FlyBase ID
FBal0268977
Feature type
allele
Associated gene
Dmel\Src42A
Associated Insertion(s)
Carried in Construct
P{NIG.7873R}
Also Known As
UAS-src42A-IR
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.7873R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-7873R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Reducing expression of Src42A (through expression of Src42ANIG.7873R under the control of Scer\GAL4btl.PS and one copy of Src42A26-1) delays the extension of the dorsal branch so that it lags behind the normally concurrent process of dorsal closure. The dorsal branch also contains fewer stalk cells. The dorsal trunk is a zigzag shape.

      (Shindo et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Loss of Src42A, through expression of Src42ANIG.7873R, dramatically suppresses tumour cell invasion into the ventral nerve cord found in Ras85DV12.Scer\UAS/l(2)gl4 mutants and enables the animals to survive to the pupal stage, whereas the tumour size remains largely unaffected.

      (Ma et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Src42ANIG.7873R
      Name Synonyms
      Secondary FlyBase IDs
        References (7)