FlyBase Allele Report: Dmel\Src42A[26-1]

General Information

Symbol

Dmel\Src42A^26-1

Species

D. melanogaster

Name

FlyBase ID

FBal0190441

Feature type

allele

Associated gene

Dmel\Src42A

Associated Insertion(s)

Carried in Construct

Also Known As

Src42^26-1

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Takahashi et al., 2005)

Mutagen

Progenitor genotype

Src42A^k10108

(Takahashi et al., 2005)

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in deletion of a 1.9 kb region containing the putative TATA box, RNA start, the first exon of Src42A and the entire P{lacW} element.

(Takahashi et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | embryonic stage 16

(Yang et al., 2019)

lethal

(Takahashi et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

In Src42A^26-1/+ wandering third instar larvae CadN-immunopositive adherens junctions between photoreceptor precursor cells R3 and R4 in row 5 have similar lengths as wild-type controls.

(Pütz, 2019)

In the tracheal dorsal trunk of Src42A^26-1 stage 16 embryos, tube length is decreased, tube diameter is increased, cell apical surface area is reduced and cell apical orientations are oriented more circumferentially, but the overall A-P cell apical orientation gradient is still present, and the cell apical aspect ratio and tube surface area are largely unchanged, as compared to controls.

(Yang et al., 2019)

Src42A^26-1 mutant embryos exhibit dorsal trunk elongation defects.

(Förster and Luschnig, 2012)

Reducing expression of Src42A (through expression of Src42A^NIG.7873R under the control of Scer\GAL4^btl.PS and one copy of Src42A^26-1) delays the extension of the dorsal branch so that it lags behind the normally concurrent process of dorsal closure. The dorsal branch also contains fewer stalk cells. The dorsal trunk is a zigzag shape.

(Shindo et al., 2008)

Src42A^26-1 embryos show mild dorsal closure defects and occasional segmental misalignment. These embryos have a slightly irregular midline. During dorsal closure the dorsal-most epidermal cells and the leading-edge structure appears normal.

(Takahashi et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval segmentation phenotype phenotype, enhanceable by Src64B[+]/Src64B^PI

(Sotillos et al., 2013)

Suppressor of

Statement

Reference

Src42A^26-1/Src42A[+] is a suppressor | partially of abnormal neuroanatomy | wandering third instar larval stage phenotype of mbt^P1

(Pütz, 2019)

Src42A^26-1/Src42A[+] is a suppressor | partially of abnormal cell adhesion | wandering third instar larval stage phenotype of mbt^P1

(Pütz, 2019)

Src42A^26-1/Src42A[+] is a suppressor | partially of abnormal size | wandering third instar larval stage phenotype of mbt^P1

(Pütz, 2019)

Other

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval segmentation phenotype phenotype

(Sotillos et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval spiracle phenotype, enhanceable by Src64B[+]/Src64B^PI

(Sotillos et al., 2013)

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic head phenotype, enhanceable by Src64B[+]/Src64B^PI

(Sotillos et al., 2013)

Src42A^26-1 has embryo | dorsal closure stage phenotype, enhanceable by Src64B[+]/Src64B^PI

(Takahashi et al., 2005)

NOT Enhancer of

Statement

Reference

Src42A^26-1 is a non-enhancer of nurse cell phenotype of Src64B^PI

(Takahashi et al., 2005)

Suppressor of

Statement

Reference

Src42A^26-1/Src42A[+] is a suppressor | partially of photoreceptor R3 precursor cell | wandering third instar larval stage phenotype of mbt^P1

(Pütz, 2019)

Src42A^26-1/Src42A[+] is a suppressor | partially of photoreceptor R4 precursor cell | wandering third instar larval stage phenotype of mbt^P1

(Pütz, 2019)

Src42A^26-1/Src42A[+] is a suppressor | partially of adherens junction | wandering third instar larval stage phenotype of mbt^P1

(Pütz, 2019)

Other

Statement

Reference

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic head phenotype

(Sotillos et al., 2013)

Src42A^26-1/Src42A[+], Stat92E⁰⁶³⁴⁶ has embryonic/larval spiracle phenotype

(Sotillos et al., 2013)

Src42A^26-1, Src64B[+]/Src64B^PI has embryonic leading edge cell phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B[+]/Src64B^PI has embryonic head phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B[+]/Src64B^PI has Bolwig organ phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B[+]/Src64B^PI has tracheal branch primordium phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B^PI has mitotic domain 1 | extended germ band stage phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B^PI has embryonic leading edge cell phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B^PI has embryonic head phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B^PI has Bolwig organ phenotype

(Takahashi et al., 2005)

Src42A^26-1, Src64B^PI has tracheal branch primordium phenotype

(Takahashi et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Src42A^26-1/+ ; Src64B^PI/+ double heterozygous embryos have normal cuticles.

Src42A^26-1/+ ; Stat92E⁰⁶³⁴⁶/+ double heterozygous embryos show defects in head formation and have segmentation and spiracle defects. This phenotype is enhanced if the embryos are also heterozygous for Src64B^PI.

(Sotillos et al., 2013)

34% of Src42A^26-1; Src64B^PI/+ embryos show a dorsal open phenotype and head involution defects. These embryos have misrouted longitudinal axons, but appear to have a normal number of neurons. The formation of Bolwig's organ and the trachea is significantly disrupted. Src42A^26-1; Src64B^PI embryos show more severe phenotypes than Src42A^26-1; Src64B^PI/+ embryos, with no germband retraction. Src42A^26-1; Src64B^PI/+ embryos exhibit almost normal cell-shape change at 9 hours AEL, but at later stages the leading edge is frequently kinked with partial dorsal-most epidermal cell deformation.

(Takahashi et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Src42A^26-1 is rescued by Src42A^UAS.Ta/Scer\GAL4^arm.PS

(Takahashi et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

90939

w^*; Src42A^26-1/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Src42^26-1

(Pütz, 2019, Yang et al., 2019)

Src42A^26-1

(Chandran et al., 2023, Chen et al., 2019, Förster and Luschnig, 2012, Shindo et al., 2008)

Src42A^26.1

(Sotillos et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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