FB2026_02 , released June 18, 2026
Allele: Dmel\Src42ADN.UAS
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General Information
Symbol
Dmel\Src42ADN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0268978
Feature type
allele
Associated gene
Dmel\Src42A
Associated Insertion(s)
Carried in Construct
P{UAS-Src42A.DN}
Also Known As
Src42ADN
Key Links
Transgenic product class
dominant_negative_variant
(Shindo et al., 2008)
missense_variant
(Shindo et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Shindo et al., 2008)
missense_variant
(Shindo et al., 2008)
Mutagen
in vitro construct
(Shindo et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Src42A.DN}
Cytology
Description

UASt regulatory sequences drive expression of a dominant negative form of Src42A, in which the lysine at position 295 has been replaced by methionine (K295M).

(Shindo et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Src42A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wandering third instar larvae expressing Src42ADN.UAS under the control of Scer\GAL4GMR.PF display CadN-immunopositive adherens junctions between photoreceptor precursor cells R3 and R4 in row 5 with similar lengths as wild-type controls.

      (Pütz, 2019)

      Dorsal trunk length is significantly reduced in embryos expressing Src42AScer\UAS.DN in the trachea under the control of Scer\GAL4btl.PS.

      (Förster and Luschnig, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Src42ADN.UAS/Scer\GAL4btl.PS rescues Src42AF80

      (Förster and Luschnig, 2012)

      Src42ADN.UAS/Scer\GAL4Abd-B-LDN rescues Src42AF80

      (Förster and Luschnig, 2012)
      Comments

      Expression of Src42AScer\UAS.DN under the control of Scer\GAL4btl.PS rescues the shortened dorsal trunk and transverse connective phenotypes seen in Src42AF80 mutant embryos. Expressing Src42AScer\UAS.DN in just three posterior body segments (tracheal metameres 7-10) under the control of Scer\GAL4Abd-B-LDN restores tube elongation only in the corresponding segments. Adjacent anterior metameres remain short.

      (Förster and Luschnig, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Src42ADN.Scer\UAS
      Src42ADN.UAS
      Src42ADN
      (Tsarouhas et al., 2019)
      Src42AScer\UAS.DN
      Name Synonyms
      Secondary FlyBase IDs
        References (8)