FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\GαoGTP.C351G.UAS
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General Information
Symbol
Dmel\GαoGTP.C351G.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0269030
Feature type
allele
Associated gene
Dmel\Gαo
Associated Insertion(s)
Carried in Construct
P{UAS-Gαo.GTP.C351G}
Key Links
Transgenic product class
missense_variant
(Yoshiura et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Yoshiura et al., 2012)
Mutagen
in vitro construct
(Yoshiura et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Gαo.GTP.C351G}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of Gαo which contains the amino acid replacements C351G (resulting in Bper\ptxA-resistance) and Q205L (producing a constitutive GTP-bound form of the protein).

(Yoshiura et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Gαo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of G-oα47AGTP.C351G.Scer\UAS does not rescue the defects in the orientation of neuroblast cell polarity which are seen in embryos expressing Bper\ptxAact.Scer\UAS under the control of Scer\GAL4sca.PU.

      (Yoshiura et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      G-oα47AGTP.C351G.Scer\UAS
      GαoGTP.C351G.Scer\UAS
      GαoGTP.C351G.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)