FB2025_05 , released December 11, 2025
Allele: Dmel\MadUAS.Tag:FLAG
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General Information
Symbol
Dmel\MadUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0269039
Feature type
allele
Associated gene
Dmel\Mad
Associated Insertion(s)
Carried in Construct
P{UAS-Mad.FLAG}
Key Links
Transgenic product class
wild_type
(Oh and Irvine, 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Oh and Irvine, 2011)
Mutagen
in vitro construct
(Oh and Irvine, 2011)
Progenitor genotype
Carried in construct
P{UAS-Mad.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of Mad tagged with Tag:FLAG.

(Oh and Irvine, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mad
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MadScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PF has no significant effect on eye size.

      (Oh and Irvine, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of MadScer\UAS.T:Zzzz\FLAG enhances the eye overgrowth seen when ykiS111A.S250A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4GMR.PF.

      Co-expression of MadScer\UAS.T:Zzzz\FLAG and tkvQ253D.Scer\UAS.cNc in wing disc clones under the control of Scer\GAL4Scer\FRT.Act5C modestly enhances growth in lateral regions.

      Expression of ykiS111A.S250A.Scer\UAS.T:SV5\V5 enhances the overgrowth seen in wing disc clones expressing MadScer\UAS.T:Zzzz\FLAG and tkvQ253D.Scer\UAS.cNc under the control of Scer\GAL4Scer\FRT.Act5C. The phenotype seen in stronger than is seen when ykiS111A.S250A.Scer\UAS.T:SV5\V5 is expressed alone.

      Co-expression of tkvQ253D.Scer\UAS.cNc and MadScer\UAS.T:Zzzz\FLAG does not suppress the growth and survival defects seen when brkScer\UAS.cJa is expressed in wing disc clones under the control of Scer\GAL4Scer\FRT.Act5C.

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 partially suppresses the underproliferation seen when brkScer\UAS.cJa is expressed in wing disc clones under the control of Scer\GAL4Scer\FRT.Act5C. Co-expression of tkvQ253D.Scer\UAS.cNc suppresses the growth defects further, producing some clone overgrowth, whilst the addition of MadScer\UAS.T:Zzzz\FLAG increases clone overgrowth even further.

      Co-expression of MadScer\UAS.T:Zzzz\FLAG and tkvQ253D.Scer\UAS.cNc suppresses the small eye phenotype seen when brkScer\UAS.cJa is expressed under the control of Scer\GAL4GMR.PF.

      (Oh and Irvine, 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MadScer\UAS.T:Zzzz\FLAG
      MadUAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)