FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SNCAA56P.UAS.cKa
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General Information
Symbol
Hsap\SNCAA56P.UAS.cKa
Species
H. sapiens
Name
FlyBase ID
FBal0269387
Feature type
allele
Associated gene
Hsap\SNCA
Associated Insertion(s)
Carried in Construct
M{UAS-αSyn.A56P}
Key Links
Transgenic product class
missense_variant
(Karpinar et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Karpinar et al., 2009)
Mutagen
in vitro construct
(Karpinar et al., 2009)
Progenitor genotype
Carried in construct
M{UAS-αSyn.A56P}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of Hsap\SNCA (amino acid replacement A56P).

(Karpinar et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\SNCA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  synucleinopathy
      CEA
      (Karpinar et al., 2009)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Mutations in Hsap\SNCA (based on a structure-based design rationale) which increase neurotoxicity, show reduced fibril and β-structure formation and increased soluble oligomers in vitro.

      (Karpinar et al., 2009)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Hsap\SNCAA56P.Scer\UAS.cKa under the control of Scer\GAL4Ddc.PL results in significant decreases in adult lifespan, as compared to controls.

      (Karpinar et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\SNCAA56P.Scer\UAS.cKa
      Hsap\SNCAA56P.UAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)