Infection of flies expressing PGRP-SC1a^{dsRNA.Scer\UAS} (under the control of Scer\GAL4^da.G32) with gram-negative bacteria induces an over-activation of the IMD pathway. This phenotype is not observed in non-infected flies or after pricking with a clean needle.

Flies expressing PGRP-SC1a^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 do not exhibit increased susceptibility to E.cloacae, E.coli or B.subtilis infection.

Mortality is 3-4 times higher in Scer\GAL4^da.G32>PGRP-SC1a^{dsRNA.Scer\UAS} larvae fed with E.coli or E.carotovora carotovora than in controls. A small percentage of the larvae that pupariate and eclose as pharate adults present developmental defects such as wing notching. Wing discs from flies fed with bacteria exhibit higher levels of cell death than controls.

PGRP-SC1a^RNAi.UAS, Scer\GAL4^da.G32 has abnormal immune response phenotype, suppressible by PGRP-LC^ΔE