FlyBase Allele Report: Dmel\Ephrin[RS5]

General Information

Symbol

Dmel\Ephrin^RS5

Species

D. melanogaster

Name

FlyBase ID

FBal0269901

Feature type

allele

Associated gene

Dmel\Ephrin

Associated Insertion(s)

P{RS5}Ephrin^RS5

Carried in Construct

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Dearborn et al., 2012)

Mutagen

Delta2-3 transposase

(Dearborn et al., 2012)

Progenitor genotype

Associated Insertion(s)

P{RS5}Ephrin^RS5

Cytology

Description

Local transposition of an unspecified P{RS5} element located adjacent to the Ephrin locus introduces the P{RS5} element into the 5' UTR of Ephrin, within the first exon. This allele exhibits a robust reduction of approximately 50% in Ephrin transcript levels.

(Dearborn et al., 2012)

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage

(Dearborn et al., 2012)

viable

(Dearborn et al., 2012)

Phenotype Manifest In

lobula | third instar larval stage

(Dearborn et al., 2012)

medulla anlage | third instar larval stage

(Dearborn et al., 2012)

Detailed Description

Statement

Reference

Homozygotes are viable with normal external adult morphology. While these animals display normal ommatidial development, cortical axon misprojection in the medulla results in neuropil gaps and ectopic axons in the cortical cell body layer, and photoreceptor axon projection defects are observed in the lamina.

Only 12% of Ephrin^RS5 mutants examined exhibit multiple gaps in the medulla neuropil, while most have no gaps. 24% of mutants show moderate defects and 47% show mild defects in lobula architecture. Large HRP[+] cortical inclusions are rare.

(Dearborn et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ephrin^RS5 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Reph¹/Reph[+]

(Dearborn et al., 2012)

Ephrin^RS5 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by Reph^k08617A/Reph[+]

(Dearborn et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ephrin^RS5 has lobula | third instar larval stage phenotype, enhanceable by Reph¹/Reph[+]

(Dearborn et al., 2012)

Ephrin^RS5 has lobula | third instar larval stage phenotype, enhanceable by Reph^k08617A/Reph[+]

(Dearborn et al., 2012)

Ephrin^RS5 has medulla anlage | third instar larval stage phenotype, enhanceable by Reph¹/Reph[+]

(Bettencourt da Cruz et al., 2008)

Ephrin^RS5 has medulla anlage | third instar larval stage phenotype, enhanceable by Reph^k08617A/Reph[+]

(Bettencourt da Cruz et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

All optic lobe phenotypic features associated with Ephrin^RS5 are exacerbated by heterozygosity for Reph¹ or Reph^k08617A.

(Dearborn et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ephrin^RS5

ephrin^RS5

(Dearborn et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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