FlyBase Allele Report: Dmel\Reph[1]

General Information

Symbol

Dmel\Reph¹

Species

D. melanogaster

Name

FlyBase ID

FBal0269897

Feature type

allele

Associated gene

Dmel\Reph

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl nitrosourea

Nature of the Allele

Allele class

Mutagen

ethyl nitrosourea

(Dearborn et al., 2012)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Dearborn et al., 2012)

lethal - all die during embryonic stage

(Dearborn et al., 2012)

partially lethal - majority die (with Reph^k16918)

(Dearborn et al., 2012)

some die during embryonic stage

(Dearborn et al., 2012)

Phenotype Manifest In

larval longitudinal connective | embryonic stage

(Dearborn et al., 2012)

symmetrical commissure | embryonic stage

(Dearborn et al., 2012)

Detailed Description

Statement

Reference

Frequent defects in the ladder-like organization of commissural and longitudinal connectives are observed in homozygous embryos.

(Dearborn et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Reph¹/Reph[+] is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Ephrin^RS5

(Dearborn et al., 2012)

Reph¹/Reph[+] is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Eph^KD

(Dearborn et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Reph¹/Reph[+] is an enhancer of lobula | third instar larval stage phenotype of Ephrin^RS5

(Dearborn et al., 2012)

Reph¹/Reph[+] is an enhancer of lobula | third instar larval stage phenotype of Eph^KD

(Dearborn et al., 2012)

Reph¹/Reph[+] is an enhancer of medulla anlage | third instar larval stage phenotype of Ephrin^RS5

(Bettencourt da Cruz et al., 2008)

Reph¹/Reph[+] is an enhancer of medulla anlage | third instar larval stage phenotype of Eph^KD

(Bettencourt da Cruz et al., 2008)

Suppressor of

Statement

Reference

Reph¹ is a suppressor of eye phenotype of Ephrin^UAS.cDa, Scer\GAL4^hs.2sev

(Dearborn et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype of Scer\GAL4^hs.2sev, Ephrin^Scer\UAS.cDa flies is strongly suppressed by Reph¹.

All optic lobe phenotypic features associated with Ephrin^RS5 or Eph^KD are exacerbated by heterozygosity for Reph¹.

(Dearborn et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Reph¹ is rescued by Scer\GAL4^elav.PU/Reph^UAS.cDa

(Dearborn et al., 2012)

Comments

Scer\GAL4^elav.PU-mediated expression of Reph^Scer\UAS.cDa rescues the homozygous lethality of Reph¹.

(Dearborn et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Reph¹

reph¹

(Dearborn et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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