FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wocD1
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General Information
Symbol
Dmel\wocD1
Species
D. melanogaster
Name
FlyBase ID
FBal0270092
Feature type
allele
Associated gene
Dmel\woc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Noyes et al., 2011)
Mutagen
ethyl methanesulfonate
(Noyes et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: P971S.

(Noyes et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      wocD1 is a non-suppressor of visible | adult stage phenotype of wa

      (Noyes et al., 2011)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      wocD1 is a non-suppressor of eye phenotype of wa

      (Noyes et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wocD1 dominantly suppresses the loss of eye colour (pairing-sensitive silencing) seen in P{wen.8}10C. The eye colour becomes darker when flies are either homozygous or heterozygous for P{wen.8}10C.

      wocD1 is unable to dominantly suppress the pairing-sensitive silencing (loss of eye colour) seen in 14/15 insertion lines containing the wP1\loxP.en.8 construct. However the eye colour of one insertion, P{(loxP.en.8)w}8A, is suppressed by wocD1, resulting in eyes with a slightly darker colour. wocD1 has no effect on the eye colour of flies carrying the P{(-loxP.en.8)w}8A insertion, in which the PRE element from P{(loxP.en.8)w}8A has been removed using CRE recombinase.

      One copy of wocD1 has no effect on the eye colour seen in flies carrying P{EP}EP2185.

      wocD1 does not suppress the eye colour phenotype seen in wa mutant flies.

      (Noyes et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wocD1
      Name Synonyms
      wocDominant1
      (Noyes et al., 2011)
      Secondary FlyBase IDs
        References (1)