FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mmp1F1.C93A.UAS
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General Information
Symbol
Dmel\Mmp1F1.C93A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0270267
Feature type
allele
Associated gene
Dmel\Mmp1
Associated Insertion(s)
Carried in Construct
P{UAS-Mmp1.F1.C93A}
Key Links
Transgenic product class
missense_variant
(Schmidt et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Schmidt et al., 2011)
Mutagen
in vitro construct
(Schmidt et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-Mmp1.F1.C93A}
Cytology
Description

Amino acid replacement: C93A.

(Schmidt et al., 2011)

UAS regulatory sequences drive expression of a constitutively active form of the Mmp1 F1 splice form.

(Schmidt et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mmp1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Mmp1F1.C93A.Scer\UAS in the larval fat body, anterior lobe of the lymph gland and circulating hemocytes under the control of Scer\GAL4yolk are larval lethal and exhibit fat-body histolysis phenotypes.

      Flies expressing Mmp1F1.C93A.Scer\UAS in the larval fat body under the control of Scer\GAL4Cg.PA exhibit severe internal tissue damage and histolysis, despite no melanization phenotype being observed.

      (Schmidt et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmp1F1.C93A.Scer\UAS
      Mmp1F1.C93A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)