FB2026_02 , released June 18, 2026
Allele: Dmel\Ctr1BNIG.7459R
Open Close
General Information
Symbol
Dmel\Ctr1BNIG.7459R
Species
D. melanogaster
Name
FlyBase ID
FBal0275579
Feature type
allele
Associated gene
Dmel\Ctr1B
Associated Insertion(s)
Carried in Construct
P{NIG.7459R}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Japanese National Institute of Genetics, 2012.5.21)
Mutagen
in vitro construct
(Japanese National Institute of Genetics, 2012.5.21)
Progenitor genotype
Carried in construct
P{NIG.7459R}
Cytology
Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-7459R
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Lang et al., 2013)
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Xiao et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Ctr1BNIG.7459R/Scer\GAL4GMR.PU is a non-suppressor of phenotype of Zzzz\CAG99.UAS.Tag:MYC,Tag:FLAG

      (Xiao et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Ctr1BNIG.7459R ameliorates the climbing defects and reduced lifespan of adults expressing Hsap\APPAβ1-42.Scer\UAS.cIa under the control of Scer\GAL4elav.PU.

      (Lang et al., 2013)

      Co-expression of Ctr1BNIG.7459R partially suppresses the mobility defects of flies expressing Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4elav.PU.

      Co-expression of Ctr1BNIG.7459R partially suppresses loss of eye pigmentation and progressive loss of rhabdomeres seen in flies expressing Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4GMR.PU.

      Co-expression of Ctr1BNIG.7459R suppresses the aggregation of Hsap\HTTQ93.ex1p.Scer\UAS protein seen in the brains of flies expressing Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4elav.PU.

      Co-expression of Ctr1BNIG.7459R has no effect on the reduction in lifespan seen in flies expressing Hsap\HTTM8V.H82A.Q127.ex1p.Scer\UAS under the control of Scer\GAL4elav.PU at 29[o]C.

      Co-expression of Ctr1BNIG.7459R has no effect on the mobility defects seen in flies expressing Hsap\HTTM8V.H82A.Q127.ex1p.Scer\UAS under the control of Scer\GAL4elav.PU at 29[o]C.

      Co-expression of Ctr1BNIG.7459R has no effect on the loss of eye pigmentation seen in flies expressing Hsap\HTTM8V.H82A.Q127.ex1p.Scer\UAS under the control of Scer\GAL4GMR.PU at 29[o]C.

      (Xiao et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ctr1BNIG.7459R
      Name Synonyms
      Secondary FlyBase IDs
        References (3)