FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\shgUASp.cJa
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General Information
Symbol
Dmel\shgUASp.cJa
Species
D. melanogaster
Name
FlyBase ID
FBal0276799
Feature type
allele
Associated gene
Dmel\shg
Associated Insertion(s)
Carried in Construct
P{UASp-shg.J}
Key Links
Transgenic product class
cDNA
(Ji and Tulin, 2012)
wild_type
(Ji and Tulin, 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ji and Tulin, 2012)
wild_type
(Ji and Tulin, 2012)
Mutagen
in vitro construct
(Ji and Tulin, 2012)
Progenitor genotype
Carried in construct
P{UASp-shg.J}
Cytology
Description

UASp regulatory sequences drive expression of a shg cDNA without its 5' UTR.

(Ji and Tulin, 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
shg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of shgScer\UAS.P\T.cJa in the germline using Scer\GAL4nos.UTR.T:Hsim\VP16 is sufficient to rescue the oocyte mislocalisation in Parg27.1 mutant follicles, including the polar cells and germline cell clones.

      Expression of shgScer\UAS.P\T.cJa in the germline under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 is sufficient to restore normal oocyte localisation in Hrb98DEd05172/Df(3R)Exel6209 mutants. shgScer\UAS.P\T.cJa-expression in the germline suppresses all the oocyte and egg chamber abnormalities associated with Hrb98DEd05172/Df(3R)Exel6209.

      Expression of shgScer\UAS.P\T.cJa in the germline under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fully rescues the oocyte mislocalisation in Parg27.1/+; Hrb98DEd05172/Df(3R)Exel6209 mutants.

      Ectopic expression of shgScer\UAS.P\T.cJa in the germline under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 significantly increased the germline stem cell self-renewal ability of Hrb98DEd05172/Df(3R)Exel6209 mutants.

      Expression of shgScer\UAS.P\T.cJa in the germline under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fully restores the germline stem cell maintenance ability in Parg27.1/+; Hrb98DEd05172/Df(3R)Exel6209 mutants.

      With expression of shgScer\UAS.P\T.cJa in germline cells under the control of Scer\GAL4nos.UTR.T:Hsim\VP16, the Parg27.1 mutant GSCs are still maintained in 65% of germaria 2 weeks after clone induction, which is comparable to the maintenance rate of the marked wild-type GSCs.

      (Ji and Tulin, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      shgScer\UAS.P\T.cJa
      shgUASp.cJa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)