FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Zzzz\CAGterm93.UAS
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General Information
Symbol
Zzzz\CAGterm93.UAS
Species
a. artificial
Name
FlyBase ID
FBal0276809
Feature type
allele
Associated gene
Zzzz\CAG
Associated Insertion(s)
Carried in Construct
P{UAS-CAG.term93}
Transgenic product class
trinucleotide_repeat_expansion
(McLeod et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
trinucleotide_repeat_expansion
(McLeod et al., 2005)
Mutagen
in vitro construct
(McLeod et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-CAG.term93}
Cytology
Description

UASt regulatory sequences drive expression of a Zzzz\CAG-variant where a termination codon is inserted immediately upstream of the CAG repeats having the effect of moving the CAG repeats into the 3'-untranslated region of the transcript.

(McLeod et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Zzzz\CAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      DOES NOT model  neurodegenerative disease
      CEA
      (van Eyk et al., 2011)
      model of  neurodegenerative disease
      CEA with sggUAS.cBa
      (van Eyk et al., 2011)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      The Zzzz\CAGterm93.Scer\UAS allele containing untranslated CAG repeats is not pathogenic when introduced into Drosophila, supporting the identity of polyglutamine as the pathogenic agent in Drosophila models of expanded CAG repeat neurodegenerative diseases.

      (McLeod et al., 2005)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Zzzz\CAGterm93.Scer\UAS under the control of Scer\GAL4GMR.PFa does not cause a visible disruption to the external patterning of the eye.

      (van Eyk et al., 2011)

      When Zzzz\CAGterm93.Scer\UAS is expressed in the eye under the control of Scer\GAL4GMR.PF, no abnormalities are observed compared to controls.

      (McLeod et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Zzzz\CAGterm93.UAS/Scer\GAL4GMR.PFa is an enhancer of eye phenotype of Scer\GAL4GMR.PFa, sggUAS.cBa

      (van Eyk et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Mef2GD5039 with Zzzz\CAGterm93.Scer\UAS under the control of Scer\GAL4GMR.PFa does not disrupt eye patterning.

      Co-expression of mod(mdg4)GD16547 with Zzzz\CAGterm93.Scer\UAS under the control of Scer\GAL4GMR.PFa does not disrupt eye patterning.

      Overexpression of sggScer\UAS.cBa under the control of Scer\GAL4GMR.PFa and in the presence of Zzzz\CAGterm93.Scer\UAS results in a decrease in the amount of pigmentation in the eye compared with overexpression of sggScer\UAS.cBa alone. There is a marked increase in the degree of roughness of the surface of the eye in flies co-expressing sggScer\UAS.cBa and Zzzz\CAGterm93.Scer\UAS.

      (van Eyk et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Zzzz\CAGterm93.Scer\UAS
      Zzzz\CAGterm93.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)