FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Aos1N2
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General Information
Symbol
Dmel\Aos1N2
Species
D. melanogaster
Name
FlyBase ID
FBal0276844
Feature type
allele
Associated gene
Dmel\Aos1
Associated Insertion(s)
TI{TI}Aos1N2
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Kanakousaki and Gibson, 2012)
Mutagen
ends-out gene targeting
(Kanakousaki and Gibson, 2012)
Progenitor genotype
Associated Insertion(s)
TI{TI}Aos1N2
Cytology
Description

A 591bp fragment of Aos1 (starting 90bp before the ATG codon and removing the whole of the first exon and most of the second exon) has been deleted and replaced by a mini-w marker.

(Kanakousaki and Gibson, 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:12,433,231..12,433,821 [-]
Comment:

A 591 bp deletion created by end-out gene targeting. It starts 90 bp before the ATG of Aos1 and removes all of exon 1 and most of exon 2, replacing it with a mini-w marker.

(Kanakousaki and Gibson, 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous larvae show loss of all imaginal discs and have severely reduced optic lobes. Overall larval growth is not affected. The animals die prior to puparium formation after a prolonged larval wandering stage. Salivary gland cells of homozygous larvae show levels of DNA synthesis comparable to controls (as assayed by EdU incorporation).

      (Kanakousaki and Gibson, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Aos1c06048

      (Kanakousaki and Gibson, 2012)
      Rescued by

      Aos1N2 is rescued by Aos1+t2.9

      (Kanakousaki and Gibson, 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Aos1N2
      aos1N2
      (Kanakousaki and Gibson, 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)