FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\APPAβ40.UAS.cSa.Tag:SS(nec)
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General Information
Symbol
Hsap\APPAβ40.UAS.cSa.Tag:SS(nec)
Species
H. sapiens
Name
FlyBase ID
FBal0276875
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
M{UAS-Aβ40.S}
Also Known As
Aβ40, UAS-Aβ40
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Speretta et al., 2012)
Progenitor genotype
Carried in construct
M{UAS-Aβ40.S}
Cytology
Description

UAS regulatory sequences drive expression of the Tag:SS(nec) secretory signal peptide followed by a single copy of the 40 amino acid residue form of Aβ (amyloid β).

(Speretta et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APP
Tagged with
Tag:SS(nec)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease 1
      CEC
      (Wacker et al., 2014)
      CEA
      (Younan et al., 2018)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Alzheimer's disease 1
      is exacerbated by Zzzz\VHHKW1.UAS.Tag:SS(nec),Tag:MYC
      (Wacker et al., 2014)
      is exacerbated by Oari\PrPVRQ.UAS
      (Younan et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Young flies (up to 22 days after eclosion) expressing Hsap\APPAβ40.Scer\UAS.att under the control of Scer\GAL4elav-C155 exhibit robust circadian rhythmicity in constant darkness (DD) that is essentially identical to that observed in control flies. A subpopulation of flies develop arrhythmic behavior by 32 days after eclosion. Overall locomotor activity is unaffected. Locomotor rhythm in DD is comparable to controls when Hsap\APPAβ40.Scer\UAS.att is expressed under the control of Scer\GAL4tim.PE or Scer\GAL4P2.4.Pdf.

      (Chen et al., 2014)

      Flies expressing either one or two copies of Hsap\APPAβ40.Scer\UAS.att under the control of Scer\GAL4GMR.PF do not accumulate significant quantities of SDS-insoluble deposits in the head.

      Flies expressing two copies of Hsap\APPAβ40.Scer\UAS.att under the control of Scer\GAL4GMR.PF have wild-type eyes.

      Flies expressing two copies of Hsap\APPAβ40.Scer\UAS.att under the control of Scer\GAL4elav-C155 do not have a significantly different life span compared to wild-type controls.

      (Speretta et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Hsap\APPAβ40.Scer\UAS.att
      Hsap\APPAβ40.Scer\UAS.cSa.T:SS-nec
      Hsap\APPAβ40.Scer\UAS.cSa
      Hsap\APPAβ40.UAS.cSa.Tag:SS(nec)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)