FB2025_05 , released December 11, 2025
Allele: Dmel\ed::shgUAS.cCa
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General Information
Symbol
Dmel\ed::shgUAS.cCa
Species
D. melanogaster
Name
FlyBase ID
FBal0276910
Feature type
allele
Associated gene
ed::shg
Associated Insertion(s)
Carried in Construct
P{UAS-ed::shg.C}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Chang et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-ed::shg.C}
Cytology
Description

UAS regulatory sequences drive expression of the transmembrane domain of ed and the intracellular domain of shg.

(Chang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ed::shg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ed::shgScer\UAS.cCa under the control of Scer\GAL4en-e16E enhances shg endocytosis in the wing disc posterior compartment. Flip-out clones expressing ed::shgScer\UAS.cCa downregulate shg and cause mutant cells to sort out from the surrounding wild type cells.

      (Chang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4C-765/ed::shgUAS.cCa is a suppressor of wing disc | somatic clone | cell autonomous phenotype of ed1X5

      (Chang et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ubiquitous expression of ed::shgScer\UAS.cCa under the control of Scer\GAL4C-765 is unable to suppress the cell sorting phenotypes seen in ed1X5 mutant wing disc clones. An actomyosin cable still forms around the clone and the boundary between the mutant clone and neighbouring wild type cells remains smooth. Apical constriction of the clone cells is still seen.

      (Chang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ed::shgScer\UAS.cCa
      ed::shgUAS.cCa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)