FlyBase Allele Report: Dmel\ppk29[Δ]

General Information

Symbol

Dmel\ppk29^Δ

Species

D. melanogaster

Name

FlyBase ID

FBal0277049

Feature type

allele

Associated gene

Dmel\ppk29

Associated Insertion(s)

Carried in Construct

Also Known As

Δppk29

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

PBac{WH}CG13563^f02213

(Thistle et al., 2012)

ppk29^f06838

(Thistle et al., 2012)

Cytology

Description

FLP-mediated recombination between PBac{WH}CG13568^f06838 and PBac{WH}CG13563^f02213 removes the first two and part of the third exons as well as 331bp 5' of CG13568.

(Thistle et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Yuan et al., 2014)

abnormal chemosensory behavior | larval stage | recessive

(Mast et al., 2014)

abnormal courtship behavior

(Thistle et al., 2012)

abnormal locomotor behavior | larval stage | recessive

(Mast et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

ppk29^Δ mutant males show no difference in courtship intensity or preference for younger females as compared with wild type.

(Hu et al., 2015)

Homozygous ppk29^Δ mutant larvae have significantly reduced preference for larval-treated substrate, compared to controls; attraction to the secreted larval fatty acids (Z)-5-tetradecanoic acid and (Z)-7-tetradecanoic acid is significantly reduced, compared to controls.

(Mast et al., 2014)

In contrast to wild type, orb2^Δ mutant males do not exhibit inhibition of the female contact-induced male-male aggression seen in wild type males that have previously been exposed to females.

(Yuan et al., 2014)

ppk29^Δ mutant males do not show aberrant courtship towards other males.

In a 30min trial, ppk29^Δ males court females with reduced frequency and longer latency compared to controls, often with ppk29^Δ males failing to court at all.

ppk29^Δ mutant flies explosed to oe[-] males (Scer\GAL4^desat1.PB, Scer\GAL80^ts.αTub84B/W^Scer\UAS.cZa) painted with 7T, 7P, or cVA, do not exhibit differences in courtship, whereas control males exhibit a reduction in courtship. Additionally, controls increase courtship to oe[-] females painted with 7,11-HD, 7,11-ND, or 7P, whereas ppk29^Δ males show no change in behavior.

(Thistle et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

ppk29^Δ has abnormal courtship behavior phenotype, non-suppressible by ppk23^UAS.cTa/Scer\GAL4^ppk23.2.695

(Thistle et al., 2012)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Introduction of ppk23^Scer\UAS.cTa into ppk29^Δ mutants under the control of Scer\GAL4^ppk23.2.695 fails to suppress the courtship defects found in ppk29^Δ mutants.

(Thistle et al., 2012)

In proboscis extension assays, ppk23^Δ8.284 ppk29^Δ double mutant flies show no significant defects in detection of sugars, bitter compounds, salt, or water.

(Thistle et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ppk29^Δ is rescued by ppk29^UAS.cTa/Scer\GAL4^ppk23.2.695

(Thistle et al., 2012)

Partially rescued by

ppk29^Δ is partially rescued by ppk29^UAS.cTa/Scer\GAL4^GMR58F10

(Mast et al., 2014)

Comments

Expression of ppk29^Scer\UAS.cTa under the control of Scer\GAL4^ppk23.2.695 rescues the reduced female courtship found in ppk29^Δ mutant males.

(Thistle et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG13568^Δ

ppk29^Δ

(Thistle et al., 2012, Thistle et al., 2012)

Δppk29

(Hu et al., 2015, Shankar et al., 2015, Mast et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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