FlyBase Allele Report: Dmel\cv-d[13]

General Information

Symbol

Dmel\cv-d¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0277148

Feature type

allele

Associated gene

Dmel\cv-d

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Chen et al., 2012)

Mutagen

ethyl methanesulfonate

(Chen et al., 2012)

Progenitor genotype

Cytology

Description

cv-d¹³ has a four nucleotide deletion after the codon for T193 that is predicted to add 16 erroneous amino acids and a stop codon.

(Chen et al., 2012)

A 4 bp deletion after the codon for T193 which leads to a truncation that removes all of the DUF1943 and VWD domains and most of the Vg domain.

(Chen et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:15,851,565..15,851,568 [-]

Comment:

A four nucleotide deletion after codon T193.

(Chen et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Chen et al., 2012)

viable

(Chen et al., 2012)

Phenotype Manifest In

posterior crossvein

(Chen et al., 2012, Chen et al., 2012)

Detailed Description

Statement

Reference

84% of mutants have no posterior crossvein (PCV), 16% have a floating PCV, 0% have a detached PCV, 0% are normal.

(Chen et al., 2012)

Homozygotes are viable and fertile, whose only visible external defects are disruption of the posterior crossvein (either partially or wholly absent) and, occasionally, the distal tip of vein L5, and a slight variable reduction in wing size.

(Chen et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

cv-d¹³ is rescued by cv-d^UAS.Tag:V5/Scer\GAL4^Tub.PU

(Chen et al., 2012)

cv-d¹³ is rescued by cv-d^UAS.Tag:V5/Scer\GAL4^unspecified

(Chen et al., 2012)

Not rescued by

cv-d¹³ is not rescued by cv-d^{ΔDUF1943+VWD.UAS.Tag:V5}/Scer\GAL4^unspecified

(Chen et al., 2012)

cv-d¹³ is not rescued by cv-d^{ΔVWD.UAS.Tag:V5}/Scer\GAL4^unspecified

(Chen et al., 2012)

cv-d¹³ is not rescued by Scer\GAL4^unspecified/cv-d^{ΔVg.UAS.Tag:V5}

(Chen et al., 2012)

Comments

Scer\GAL4^tub.PU-mediated expression of cv-d^{Scer\UAS.T:SV5\V5} results in complete rescue of the cv-d¹³ posterior crossvein phenotype.

(Chen et al., 2012)

Scer\GAL4^unspecified-mediated expression of cv-d^{Scer\UAS.T:SV5\V5} rescues posterior crossvein development in cv-d¹³ mutants. However, Scer\GAL4^unspecified-mediated expression of cv-d^{ΔDUF1943+VWD.Scer\UAS.T:SV5\V5}, cv-d^{ΔVWD.Scer\UAS.T:SV5\V5} or cv-d^{ΔVg.Scer\UAS.T:SV5\V5} does not rescue posterior crossvein development in cv-d¹³ mutants.

(Chen et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

cv-d¹³

(Chen et al., 2012, Chen et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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