FB2026_02 , released June 18, 2026
Allele: Dmel\Claspin45
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General Information
Symbol
Dmel\Claspin45
Species
D. melanogaster
Name
FlyBase ID
FBal0277228
Feature type
allele
Associated gene
Dmel\Claspin
Associated Insertion(s)
P{?EP}Claspin45
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lee et al., 2012)
Mutagen
P-element activity
(Lee et al., 2012)
Progenitor genotype
P{EP}GE20270
(Lee et al., 2012)
Associated Insertion(s)
P{?EP}Claspin45
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion which removes the entire coding sequence of Claspin. The deletion extends to -2347bp relative to the Claspin transcription start site. Part of the original inserted P{EP} element remains.

(Lee et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:4,311,288..4,318,829 [+]
Comment:

Deletion resulting from the imprecise excision of P{EP}GE20270, extending from -2347 to +5195, where +1 is the translation start of Claspin. A portion of the EP element remains.

(Lee et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Eggs laid by homozygous females show a very low rate of hatching (0.2%). Eggs laid by Claspin45/Df(3L)Exel8098 females fail to hatch. Most embryos laid by the mutant females show normal nuclear morphology until division 10, but after this stage they begin to show an irregular distribution of surface nuclei and and have nuclei with abnormal size or shape. By division 13, less than one-third of the mutant embryos have normal nuclear morphology.

      Homozygous and Claspin45/Df(3L)Exel8098 animals show an increased frequency of generation of mutant clones compared to wild type in a loss of heterozygosity assay.

      Ionising radiation-induced G2 arrest occurs normally in homozygous eye discs. Ionising radiation-induced apoptosis occurs normally in homozygous eye discs.

      Homozygous and Claspin45/Df(3L)Exel8098 eye discs show defects in hydroxyurea-induced G2 arrest.

      Homozygous and Claspin45/Df(3L)Exel8098 larvae show reduced survival in the presence of hydroxyurea compared to wild type.

      (Lee et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Claspin45, Rpp3018.2 has lethal phenotype

      (Molla-Herman et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Claspin45
      (Lee et al., 2012)
      claspin45
      (Molla-Herman et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)