FB2026_02 , released June 18, 2026
Allele: Dmel\Top3αΔCT2.EYFP
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General Information
Symbol
Dmel\Top3αΔCT2.EYFP
Species
D. melanogaster
Name
FlyBase ID
FBal0277343
Feature type
allele
Associated gene
Dmel\Top3α
Associated Insertion(s)
Carried in Construct
P{Top3α.YFP.ΔCT2}
Key Links
Transgenic product class
inframe_deletion
(Chen et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Chen et al., 2012)
Mutagen
in vitro construct
(Chen et al., 2012)
Progenitor genotype
Top3αEYFP
(Chen et al., 2012)
Carried in construct
P{Top3α.YFP.ΔCT2}
Cytology
Description

Part of the Top3α coding sequence has been deleted, such that amino acid residues 1-768 and 1029-1250 remain. In addition the Top3α nuclear localisation sequence (amino acids 845-862) has been added back immediately preceeding the C-terminal EYFP tag.

(Chen et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
Top3α
Encoded product / tool
Top3α
Tagged with
EYFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Top3αΔCT2.EYFP partially rescues Top3α54

      (Chen et al., 2012)
      Comments

      One copy of Top3αΔCT2.T:Avic\GFP-EYFP rescues the lethality of approximately 5% of Top3α54 homozygotes. Two copies of Top3αΔCT2.T:Avic\GFP-EYFP rescue the lethality of approximately 10% of Top3α54 homozygotes.

      (Chen et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Top3αΔCT2.EYFP
      Top3αΔCT2.T:Avic\GFP-EYFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)