FB2026_02 , released June 18, 2026
Allele: Dmel\Pi4KIIαCAT.αTub84B.mCherry
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General Information
Symbol
Dmel\Pi4KIIαCAT.αTub84B.mCherry
Species
D. melanogaster
Name
FlyBase ID
FBal0277499
Feature type
allele
Associated gene
Dmel\Pi4KIIα
Associated Insertion(s)
Carried in Construct
P{αTub84B-Pi4KIIα.CAT.mCherry}
Key Links
Transgenic product class
missense_variant
(Burgess et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Burgess et al., 2012)
Mutagen
in vitro construct
(Burgess et al., 2012)
Progenitor genotype
Carried in construct
P{αTub84B-Pi4KIIα.CAT.mCherry}
Cytology
Description

The αTub84B promoter drives expression of a mutant form of Pi4KIIα in which the aspartic acid at amino acid 465 has been replaced by alanine (D465A). The construct is tagged with mCherry.

(Burgess et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
αTub84B
Encoded product / tool
Pi4KIIα
Tagged with
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      CG14671+tBa/Pi4KIIαCAT.αTub84B.mCherry fails to rescue Df(3R)730

      (Burgess et al., 2012)
      Comments

      Expression of Pi4KIIαCAT.αTub84B.T:Disc\RFP-mCherry fails to rescue the glue granule and late endosome defects seen in the salivary glands of Df(3R)730 mutant flies (in which lethality has been rescued using CG14671+tBa). Abortive tubular endosomes are formed.

      (Burgess et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pi4KIIαCAT.αTub84B.T:Disc\RFP-mCherry
      Pi4KIIαCAT.αTub84B.mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (1)