FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\parvinunspecified
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General Information
Symbol
Dmel\parvinunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0277808
Feature type
allele
Associated gene
Dmel\parvin
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        parvinunspecified is rescued by Scer\GAL4how-24B/parvinUASp.mGFP6

        (Vakaloglou et al., 2012)
        Partially rescued by

        parvinunspecified is partially rescued by Scer\GAL4how-24B/parvinΔCH1.UASp.mGFP6

        (Vakaloglou et al., 2012)

        parvinunspecified is partially rescued by Scer\GAL4how-24B/parvinΔCH2.UASp.mGFP6

        (Vakaloglou et al., 2012)

        parvinunspecified is partially rescued by parvinΔCH2.7.2.GFP

        (Vakaloglou et al., 2012)

        parvinunspecified is partially rescued by parvinCH1CH2.UASp.mGFP6/Scer\GAL4how-24B

        (Vakaloglou et al., 2012)

        parvinunspecified is partially rescued by Scer\GAL4how-24B/parvinCH1CH2.7.2.mGFP6

        (Vakaloglou et al., 2012)

        parvinunspecified is partially rescued by parvinCH2.UASp.mGFP6/Scer\GAL4how-24B

        (Vakaloglou et al., 2012)
        Not rescued by

        parvinunspecified is not rescued by Scer\GAL4how-24B/parvinN.UASp.mGFP6

        (Vakaloglou et al., 2012)

        parvinunspecified is not rescued by Scer\GAL4how-24B/parvinNCH1.UASp.mGFP6

        (Vakaloglou et al., 2012)

        parvinunspecified is not rescued by parvinCH1L.UASp.mGFP6/Scer\GAL4how-24B

        (Vakaloglou et al., 2012)
        Comments

        Expression of parvinScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4how-24B parvinunspecified animals to adulthood.

        parvin7.2.T:Avic\GFP rescues parvinunspecified animals to adulthood.

        Expression of parvinΔCH1.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4how-24B significantly rescues the embryonic lethality of parvinunspecified mutants, with up to 75% of the embryos hatching to first instar larvae. However, the rescued larvae die during the first and second instars, showing a muscle detachment phenotype.

        Expression of parvinΔCH2.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4how-24B partially rescues the embryonic lethality of parvinunspecified mutants, but the rescued larvae die soon after hatching with muscle adhesion defects.

        parvinΔCH2.7.2.T:Avic\GFP partially rescues the embryonic lethality of parvinunspecified mutants, but the rescued larvae die soon after hatching with muscle adhesion defects.

        Expression of parvinCH1CH2.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4how-24B rescues both embryogenesis and larval development in parvinunspecified animals, but the flies arrest at the pupal stage.

        parvinCH1CH2.7.2.T:Avic\GFP-m6 rescues both embryogenesis and larval development in parvinunspecified animals, but the flies arrest at the pupal stage.

        Expression of parvinCH1.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4how-24B shows poor rescue of the embryonic lethality of parvinunspecified mutants.

        Expression of parvinCH2.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4how-24B rescues the embryonic lethality of parvinunspecified mutants in almost 50% of cases.

        Expression of either parvinN.Scer\UAS.T:Avic\GFP-m6, parvinNCH1.Scer\UAS.T:Avic\GFP-m6 or parvinCH1L.Scer\UAS.T:Avic\GFP-m6 under the control of Scer\GAL4how-24B fails to rescue the embryonic lethality of parvinunspecified mutants.

        (Vakaloglou et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        parvinunspecified
        Name Synonyms
        Secondary FlyBase IDs
          References (2)