FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Same\LazUAS.cRa
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General Information
Symbol
Same\LazUAS.cRa
Species
S. americana
Name
Saccharomyces cerevisiae UAS construct a of Ruiz
FlyBase ID
FBal0278146
Feature type
allele
Associated gene
Same\Laz
Associated Insertion(s)
Carried in Construct
P{UAS-sLaz.R}
Transgenic product class
cDNA
(Ruiz et al., 2012)
wild_type
(Ruiz et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ruiz et al., 2012)
wild_type
(Ruiz et al., 2012)
Mutagen
in vitro construct
(Ruiz et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-sLaz.R}
Cytology
Description

UASt regulatory sequences drive expression of a full-length Same\Laz cDNA.

(Ruiz et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Same\Laz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal starvation stress response, with Scer\GAL4da.G32

      (Ruiz et al., 2012)

      abnormal starvation stress response, with Scer\GAL4l(3)31-1-31-1

      (Ruiz et al., 2012)

      abnormal starvation stress response, with Scer\GAL4ppl.PP

      (Ruiz et al., 2012)

      abnormal starvation stress response, with Scer\GAL4repo

      (Ruiz et al., 2012)

      abnormal starvation stress response, with Scer\GAL4repo-M1B

      (Ruiz et al., 2012)

      abnormal starvation stress response | female limited, with Scer\GAL4109(2)80

      (Ruiz et al., 2012)

      abnormal starvation stress response | female limited, with Scer\GAL4Ddc.PL

      (Ruiz et al., 2012)

      abnormal starvation stress response | male limited, with Scer\GAL4Toll-6-D42

      (Ruiz et al., 2012)

      abnormal stress response, with Scer\GAL4Ddc.PL

      (Ruiz et al., 2012)

      abnormal stress response, with Scer\GAL4ppl.PP

      (Ruiz et al., 2012)

      abnormal stress response, with Scer\GAL4repo-M1B

      (Ruiz et al., 2012)

      chemical resistant, with Scer\GAL4109(2)80

      (Ruiz et al., 2012)

      chemical resistant, with Scer\GAL4da.G32

      (Ruiz et al., 2012)

      chemical resistant | female, with Scer\GAL4Ddc.PL

      (Ruiz et al., 2012)

      chemical resistant | female, with Scer\GAL4repo-M1B

      (Ruiz et al., 2012)

      chemical sensitive, with Scer\GAL4ppl.PP

      (Ruiz et al., 2012)

      chemical sensitive | male, with Scer\GAL4Ddc.PL

      (Ruiz et al., 2012)

      long lived, with Scer\GAL4109(2)80

      (Ruiz et al., 2012)

      long lived, with Scer\GAL4da.G32

      (Ruiz et al., 2012)

      long lived, with Scer\GAL4Ddc.PL

      (Ruiz et al., 2012)

      long lived | chemical conditional, with Scer\GAL4109(2)80

      (Ruiz et al., 2012)

      long lived | chemical conditional, with Scer\GAL4da.G32

      (Ruiz et al., 2012)

      long lived | chemical conditional, with Scer\GAL4Ddc.PL

      (Ruiz et al., 2012)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Male and female flies expressing Same\LazScer\UAS.cRa under the control of either Scer\GAL4Ddc.PL or Scer\GAL4109(2)80 show an increase in median lifespan compared to controls.

      Female flies, and to a lesser extent male flies, expressing Same\LazScer\UAS.cRa under the control of Scer\GAL4da.G32 show an increase in median lifespan compared to controls.

      Expression of Same\LazScer\UAS.cRa under the control of either Scer\GAL4da.G32, Scer\GAL4repo-M1B, Scer\GAL4ppl.PP, Scer\GAL4repo or Scer\GAL4l(3)31-1-31-1 significantly increases the survival of both male and female flies upon starvation-desiccation stress.

      Expression of Same\LazScer\UAS.cRa under the control of either Scer\GAL4Ddc.PL or Scer\GAL4109(2)80 significantly increases the survival of female but not male flies upon starvation-desiccation stress.

      Expression of Same\LazScer\UAS.cRa under the control of Scer\GAL4He.PZ has no effect on starvation-desiccation resistance.

      Expression of Same\LazScer\UAS.cRa under the control of Scer\GAL4D42 significantly increases the survival of male but not female flies upon starvation-desiccation stress.

      Female, but not male, flies expressing Same\LazScer\UAS.cRa under the control of Scer\GAL4repo-M1B show increased resistance to iron toxicity (treated with FeSO[[4]]) compared to controls.

      Females expressing Same\LazScer\UAS.cRa under the control of Scer\GAL4Ddc.PL show slightly increased resistance to iron toxicity (treated with FeSO[[4]]) compared to controls, while male flies are show decreased resistance in this assay.

      Flies expressing Same\LazScer\UAS.cRa under the control of either Scer\GAL4da.G32 or Scer\GAL4109(2)80 show increased resistance to iron toxicity (treated with FeSO[[4]]) compared to controls, with the effect being stronger in females when expression is under the control of Scer\GAL4109(2)80.

      Flies expressing Same\LazScer\UAS.cRa under the control of Scer\GAL4ppl.PP show decreased resistance to iron toxicity (treated with FeSO[[4]]) compared to controls.

      Expression of Same\LazScer\UAS.cRa under the control of Scer\GAL4repo has no significant effect on resistance to iron toxicity (treated with FeSO[[4]]).

      Expression of Same\LazScer\UAS.cRa under the control of either Scer\GAL4repo-M1B, Scer\GAL4ppl.PP or Scer\GAL4Ddc.PL results in an increased resistance to hyperoxia.

      Expression of Same\LazScer\UAS.cRa under the control of either Scer\GAL4109(2)80 or Scer\GAL4da.G32 does not significantly increase resistance to hyperoxia.

      Expression of Same\LazScer\UAS.cRa under the control of either Scer\GAL4da.G32 or Scer\GAL4Ddc.PL results in a significant increase in total triglycerides content compared to controls.

      (Ruiz et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Same\LazUAS.cRa/Scer\GAL4da.G32 is a non-suppressor of abnormal courtship behavior phenotype of NLazNW5

      (Ruiz et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The increased sensitivity to starvation-desiccation and to iron toxicity (treated with FeSO[[4]]) seen in NLazNW5 homozygotes is rescued by expression of Same\LazScer\UAS.cRa under the control of Scer\GAL4da.G32. However, the courtship defects seen in NLazNW5 homozygotes are not rescued.

      (Ruiz et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Same\LazScer\UAS.cRa
      Same\LazUAS.cRa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ruiz
      Secondary FlyBase IDs
        References (1)