FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rictorΔ42
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General Information
Symbol
Dmel\rictorΔ42
Species
D. melanogaster
Name
FlyBase ID
FBal0278190
Feature type
allele
Associated gene
Dmel\rictor
Associated Insertion(s)
Carried in Construct
Also Known As
ricΔ42
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Lee and Chung, 2007)
Mutagen
P-element activity
(Lee and Chung, 2007)
Progenitor genotype
P{EP}rictorG17314
(Lee and Chung, 2007)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1.8kb deletion that removes exons 1, 2 and 3 of rictor. This deletion includes the translation start codon.

(Lee and Chung, 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neuronal ceroid lipofuscinosis 7
      modeled by Cln784D
      (Connolly et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The neuromuscular junctions of rictorΔ42 homozygous transheterozygous third instar larvae present significantly more boutons than controls.

      (Connolly et al., 2019)

      The neuromuscular junctions of homozygous rictorΔ42 mutant larvae (muscle 4 of segment A2-4) show a significant increase in synaptic growth compared to controls.

      (Natarajan et al., 2013)

      Homozygous flies show a one-day delay in eclosion compared to wild type and approximately 10% lethality in the early developmental stages. Adult body size and average body weight is significantly reduced.

      (Lee and Chung, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      rictorΔ42 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by gig109/gig109

      (Natarajan et al., 2013)
      Enhancer of
      Statement
      Reference

      rictorΔ42 is an enhancer of visible phenotype of Scer\GAL4GMR.PU, foxoUAS.cLa

      (Lee and Chung, 2007)
      NOT Enhancer of
      Suppressor of
      Statement
      Reference

      rictorΔ42 is a suppressor of visible phenotype of AktUAS.Tag:HA, Scer\GAL4GMR.PU

      (Lee and Chung, 2007)
      NOT Suppressor of
      Statement
      Reference

      rictorΔ42 is a non-suppressor of visible phenotype of S6kUAS.cWa, Scer\GAL4ap-md544

      (Lee and Chung, 2007)
      Other
      Statement
      Reference

      Akt04226, rictorΔ42 has lethal phenotype

      (Lee and Chung, 2007)
      Phenotype Manifest In
      NOT Enhanced by
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      rictorΔ42 is an enhancer of eye phenotype of Scer\GAL4GMR.PU, foxoUAS.cLa

      (Lee and Chung, 2007)

      rictorΔ42 is an enhancer of ommatidium phenotype of Scer\GAL4GMR.PU, foxoUAS.cLa

      (Lee and Chung, 2007)
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      rictorΔ42 is a non-suppressor of wing phenotype of S6kUAS.cWa, Scer\GAL4ap-md544

      (Lee and Chung, 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The synaptic growth defects seen in rictorΔ42 gig109 double mutants are similar to those seen in either mutant alone.

      (Natarajan et al., 2013)

      Homozygosity for rictorΔ42 dramatically suppresses the enlarged eye (and enlarged ommatidium) phenotype caused by expression of Akt1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU.

      The reduction in eye size and ommatidial loss caused by expression of foxoScer\UAS.cLa under the control of Scer\GAL4GMR.PU is dramatically enhanced in a rictorΔ42 background.

      The wing phenotype caused by expression of S6kScer\UAS.cWa under the control of Scer\GAL4ap-md544 is not altered in a rictorΔ42 background.

      (Lee and Chung, 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ricΔ42
      (Natarajan et al., 2013, Lee and Chung, 2007)
      rictorΔ42
      (Connolly et al., 2019, Natarajan et al., 2013, Lee and Chung, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)