FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\snS52A.UAS.mKO
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General Information
Symbol
Dmel\snS52A.UAS.mKO
Species
D. melanogaster
Name
FlyBase ID
FBal0278226
Feature type
allele
Associated gene
Dmel\sn
Associated Insertion(s)
Carried in Construct
M{UAS-mKO-sn.S52A}
Key Links
Transgenic product class
missense_variant
(Nagel et al., 2012)
polypeptide_post_translational_processing_variant
(Nagel et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Nagel et al., 2012)
polypeptide_post_translational_processing_variant
(Nagel et al., 2012)
Mutagen
in vitro construct
(Nagel et al., 2012)
Progenitor genotype
Carried in construct
M{UAS-mKO-sn.S52A}
Cytology
Description

UASt regulatory sequences drive expression of a non-phosphorylatable form of sn which contains the amino acid replacement S52A. The protein is tagged at the N-terminal end with the mKO fluorescent protein.

(Nagel et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sn
Tagged with
mKO
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Class IV ddaC neurons expressing snS52A.Scer\UAS.T:Zzzz\KO-mKO under the control of Scer\GAL4477 form shorter and straighter terminal branchlets than wild type. There is also a prominent induction of higher order branching.

      (Nagel et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      snS52A.UAS.mKO/Scer\GAL4smid-C161 rescues sn36a

      (Nagel et al., 2012)
      Comments

      Expression of snS52A.Scer\UAS.T:Zzzz\KO-mKO under the control of Scer\GAL4smid-C161 rescues the reduction in density of spiked protrusions on the dendrites of class III ldaB neurons that is seen in sn36a third instar larvae.

      (Nagel et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      snS52A.Scer\UAS.T:Vcon\KO-mKO
      snS52A.Scer\UAS.T:Zzzz\KO-mKO
      snS52A.UAS.mKO
      Name Synonyms
      Secondary FlyBase IDs
        References (3)