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General Information
Symbol
Dmel\sn36a
Species
D. melanogaster
Name
FlyBase ID
FBal0015801
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion in the 5' untranslated region.

5.5kb insertion between -1.2 and 0.0 (coordinates as in FBrf0048245).

Insertion of 5.5kb DNA, at coordinates -1.2 to 0.0.

Insertion components
?{}sn36a
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The number and density of spiked protrusions on the dendrites of class III ldaB neurons is reduced in mutant third instar larvae compared to wild type, while the total branch length of the dendritic tree is normal. The neuron terminal branchlets are bent in the mutant larvae, in contrast to wild type. The fraction of spiked protrusions that exceed 10 μm in length is increased in the mutant larvae. The complexity of the dendritic tree appears slightly increased (for example, the number of all termini excluding the terminal branchlets of less than 30 μm is significantly increased). The number of spiked protrusions on the class III neuron dendrites is also reduced in mutant second instar larvae, and a reduced rate of formation of new branchlets is seen at this stage compared to wild type.

Homozygous border cell clones show normal migration.

Bristles are gnarled due to disrupted actin filament bundles. Nurse cell cytoplasmic actin filaments are absent.

Extreme bristle phenotype, female sterile.

Macrochaetae gnarled in a fairly extreme manner. Microchaetae wild type. sn36a is only allele to cause pronounced reduction in replication of oocyte nurse cell DNA (King and Burnett, 1957). Also causes more extreme retardation of vitellogenesis than other female-sterile sn alleles (Bender, 1960). sn36a sn4 homozygote has nearly normal bristles and is sterile. RK1. class 4 - female sterile with gnarled macrochaetae only

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference

sn36a has phenotype, non-suppressible by su(Hw)2

Additional Comments
Genetic Interactions
Statement
Reference

Expression of ctScer\UAS.cPa under the control of Scer\GAL4221 in a sn36a background in class I vpda neurons results in an expansion of the dendrite tree. In addition, the formation of ectopic spiked protrusions is reduced by more than 40% compared to the expression of ctScer\UAS.cPa under the control of Scer\GAL4221 in a wild-type background.

Homozygous sn36a border cell clones in a qua1/+ background show normal migration.

Homozygous qua1 border cell clones in a sn36a/+ background show normal migration.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of snScer\UAS.T:Zzzz\KO-mKO under the control of Scer\GAL4smid-C161 rescues the reduction in number and density of spiked protrusions on the dendrites of class III ldaB neurons that is seen in sn36a third instar larvae.

Expression of snS52A.Scer\UAS.T:Zzzz\KO-mKO or snS52D.Scer\UAS.T:Zzzz\KO-mKO under the control of Scer\GAL4smid-C161 rescues the reduction in density of spiked protrusions on the dendrites of class III ldaB neurons that is seen in sn36a third instar larvae.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Spencer, 21st Jan. 1936.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (12)