FlyBase Allele Report: Dmel\futsch[HMS02000]

General Information

Symbol

Dmel\futsch^HMS02000

Species

D. melanogaster

Name

FlyBase ID

FBal0279113

Feature type

allele

Associated gene

Dmel\futsch

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02000}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02000}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02000

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased size | larval stage, with Scer\GAL4^c42

(Tiwari and Tapadia, 2026)

short lived, with Scer\GAL4^Toll-6-D42

(Coyne et al., 2014)

Phenotype Manifest In

embryonic/larval Malpighian tubule | larval stage, with Scer\GAL4^c42

(Tiwari and Tapadia, 2026)

Detailed Description

Statement

Reference

Expression of futsch^HMS02000 under the control of Scer\GAL4^D42 results in a significant reduction in lifespan.

(Coyne et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^c42, futsch^HMS02000 has increased size | larval stage phenotype, enhanceable by tau^KO/tau^KO

(Tiwari and Tapadia, 2026)

Enhancer of

Statement

Reference

Scer\GAL4^c42/futsch^HMS02000 is an enhancer of abnormal size | larval stage phenotype of tau^KO

(Tiwari and Tapadia, 2026)

NOT Suppressor of

Statement

Reference

futsch^HMS02000, Scer\GAL4^Toll-6-D42 is a non-suppressor of abnormal locomotor behavior | larval stage phenotype of Hsap\TARDBP^UAS.YFP.cEa, Scer\GAL4^Toll-6-D42

(Coyne et al., 2014)

futsch^HMS02000, Scer\GAL4^Toll-6-D42 is a non-suppressor of abnormal locomotor behavior | larval stage phenotype of Hsap\TARDBP^{G298S.UAS.YFP}, Scer\GAL4^Toll-6-D42

(Coyne et al., 2014)

Other

Statement

Reference

Scer\GAL4^c42, futsch^HMS02000, tau^KO has short lived phenotype

(Tiwari and Tapadia, 2026)

Hsap\TARDBP^{G298S.UAS.YFP}, Scer\GAL4^Toll-6-D42, futsch^HMS02000 has lethal - all die before end of pupal stage phenotype

(Coyne et al., 2014)

Hsap\TARDBP^UAS.YFP.cEa, Scer\GAL4^Toll-6-D42, futsch^HMS02000 has lethal - all die before end of pupal stage phenotype

(Coyne et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^c42, futsch^HMS02000 has embryonic/larval Malpighian tubule | larval stage phenotype, enhanceable by tau^KO/tau^KO

(Tiwari and Tapadia, 2026)

Enhancer of

Statement

Reference

Scer\GAL4^c42/futsch^HMS02000 is an enhancer of embryonic/larval Malpighian tubule | larval stage phenotype of tau^KO

(Tiwari and Tapadia, 2026)

Other

Statement

Reference

Scer\GAL4^c42, futsch^HMS02000, tau^KO has embryonic/larval Malpighian tubule | larval stage phenotype

(Tiwari and Tapadia, 2026)

Scer\GAL4^c42, futsch^HMS02000, tau^KO has microtubule | larval stage phenotype

(Tiwari and Tapadia, 2026)

Scer\GAL4^c42, futsch^HMS02000, tau^KO has filamentous actin | larval stage phenotype

(Tiwari and Tapadia, 2026)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of futsch^HMS02000 does not suppress the larval turning phenotype seen when Hsap\TARDBP^{Scer\UAS.T:Avic\GFP-YFP.cEa} is expressed under the control of Scer\GAL4^D42, but the flies are lethal at the pupal stage.

Expression of futsch^HMS02000 does not suppress the larval turning phenotype seen when Hsap\TARDBP^{G298S.Scer\UAS.T:Avic\GFP-YFP} is expressed under the control of Scer\GAL4^D42, but the flies are lethal at the pupal stage.

(Coyne et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

40834

y¹ v¹; P{TRiP.HMS02000}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

futsch^HMS02000

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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