FlyBase Allele Report: Dmel\tau[KO]

Inferred boundaries of a deletion created by ends-out homologous recombination that removes exons 2-6 of tau and replaces them with a w^+mW.hs marker.

(Burnouf et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA

(Zerva et al., 2024, Arnes et al., 2019, Papanikolopoulou et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^{Q72.ex1.UAS.cWa}

(Wen et al., 2020)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | adult stage

(Papanikolopoulou et al., 2019)

abnormal neurophysiology | adult stage

(Burnouf et al., 2016)

abnormal pain response | adult stage

(Papanikolopoulou et al., 2019)

decreased size | embryonic stage

(Hahn et al., 2021)

Phenotype Manifest In

axon | embryonic stage

(Hahn et al., 2021)

axon | embryonic stage (with Df(3R)MR22)

(Hahn et al., 2021)

axon microtubule bundle | embryonic stage

(Hahn et al., 2021)

axon microtubule bundle | embryonic stage (with Df(3R)MR22)

(Hahn et al., 2021)

microtubule plus-end | embryonic stage

(Hahn et al., 2021)

microtubule plus-end | embryonic stage (with Df(3R)MR22)

(Hahn et al., 2021)

Detailed Description

Statement

Reference

tau^KO mutant adults have significantly increased aversive olfactory 24 h memory following spaced, but not massed, training, with no effect on 3 min memory, compared to controls; they have normal naive avoidance of electric shocks, but have a significant failure to habituate to shocks, compared to controls.

(Papanikolopoulou et al., 2019)

tau^KO/tau^KO flies do not have significantly different climbing ability (locomotion) or lifespan compared to wild type.

There is no detrimental effect on response latency for signal to reach the tergotrochanteral muscle (TTM) or the dorsal longitudinal muscle (DLM) after stimulation of the giant fiber in the fly brain in tau^KO/tau^KO compared to wild type; in 15 day old mutants there is even a significantly shorter response latency in the TTM compared to wild type, though this effect is not seen in older (34 day old) flies.

(Burnouf et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^{Q72.ex1.UAS.cWa}, Scer\GAL4^elav.PLu

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-enhancer of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-enhancer of short lived phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau^KO/tau^KO is a non-enhancer of short lived | RU486 conditional phenotype of Hsap\APP^{Aβ1-42.arctic.UAS.Tag:SS(nec)}, Scer\GAL4^{elav.Switch.PO}

(Burnouf et al., 2016)

Suppressor of

Statement

Reference

tau^KO/tau^KO is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^{Q72.ex1.UAS.cWa}, Scer\GAL4^GMR61G12

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^{Q72.ex1.UAS.cWa}, Scer\GAL4^elav.PLu

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of short lived phenotype of Hsap\HTT^{Q72.ex1.UAS.cWa}, Scer\GAL4^elav.PLu

(Wen et al., 2020)

tau^KO/tau^KO is a suppressor | partially of abnormal neuroanatomy | adult stage | progressive phenotype of Scer\GAL4^GMR61G12, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of short lived phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

NOT Suppressor of

Statement

Reference

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^{Q72.ex1.UAS.cWa}, Scer\GAL4^elav.PLu

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-suppressor of short lived phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau^KO/tau^KO is a non-suppressor of short lived | RU486 conditional phenotype of Hsap\APP^{Aβ1-42.arctic.UAS.Tag:SS(nec)}, Scer\GAL4^{elav.Switch.PO}

(Burnouf et al., 2016)

Other

Statement

Reference

Eb1⁰⁴⁵²⁴, tau^KO has decreased size | embryonic stage phenotype

(Hahn et al., 2021)

msps^A, tau^KO has decreased size | embryonic stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has decreased size | larval stage phenotype

(Hahn et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype, suppressible by shot^LA.UAS.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Df(3R)MR22/tau^KO has microtubule plus-end | embryonic stage phenotype, suppressible by Eb1^UAS.cKa.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Df(3R)MR22/tau^KO has axon | embryonic stage phenotype, suppressible by Eb1^UAS.cKa.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Df(3R)MR22/tau^KO has axon microtubule bundle | embryonic stage phenotype, suppressible by Eb1^UAS.cKa.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

NOT suppressed by

Statement

Reference

Df(3R)MR22/tau^KO has microtubule plus-end | embryonic stage phenotype, non-suppressible by shot^{Ctail.UAS.GFP}/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype, non-suppressible by shot^{RE-ΔABD.UAS.GFP}/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype, non-suppressible by shot^{RE-3MtLSmut.UAS.GFP}/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

NOT Enhancer of

Statement

Reference

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-enhancer of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-enhancer of presynaptic active zone | third instar larval stage | decreased number phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-enhancer of A1-7 ventral longitudinal muscle cell | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

Suppressor of

Statement

Reference

tau^KO/tau^KO is a suppressor | partially of axon | adult stage phenotype of Hsap\HTT^{Q72.ex1.UAS.cWa}, Scer\GAL4^GMR61G12

(Wen et al., 2020)

tau^KO/tau^KO is a suppressor | partially of adult s-LNv neuron | adult stage phenotype of Hsap\HTT^{Q72.ex1.UAS.cWa}, Scer\GAL4^GMR61G12

(Wen et al., 2020)

tau^KO/tau^KO is a suppressor | partially of axon | adult stage phenotype of Scer\GAL4^GMR61G12, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau^KO/tau^KO is a suppressor | partially of adult s-LNv neuron | adult stage phenotype of Scer\GAL4^GMR61G12, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of presynaptic active zone | third instar larval stage | decreased number phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+]/tau^KO is a suppressor | partially of A1-7 ventral longitudinal muscle cell | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

NOT Suppressor of

Statement

Reference

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-suppressor of presynaptic active zone | third instar larval stage | decreased number phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

tau[+], tau^KO, Hsap\MAPT^UAS.cWa, Scer\GAL4^elav.PLu is a non-suppressor of A1-7 ventral longitudinal muscle cell | third instar larval stage phenotype of Scer\GAL4^elav.PLu, Zzzz\GGGGCC^30.UAS.EGFP

(Wen et al., 2020)

Other

Statement

Reference

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has medulla | adult stage phenotype

(Hahn et al., 2021)

msps^A, tau^KO has axon | embryonic stage phenotype

(Hahn et al., 2021)

msps^A, tau^KO has axon microtubule bundle | embryonic stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon | adult stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | adult stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has microtubule plus-end | embryonic stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has microtubule plus-end | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, tau^KO has axon | embryonic stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, tau^KO has axon microtubule bundle | embryonic stage phenotype

(Hahn et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\MAPT^UAS.cWa under the control of Scer\GAL4^elav.PLu restores the decreased life span phenotype of tau^KO/+ adults expressing Hsap\HTT^{Q72.ex1.UAS.cWa} under the control of Scer\GAL4^elav.PLu.

(Wen et al., 2020)

tau^KO/tau^KO does not significantly modulate the shorter lifespan seen in flies with Hsap\APP^{Aβ1-42.arctic.Scer\UAS.T:SS-nec} driven by Scer\GAL4^{elav.Switch.PO} in the presence of RU486.

(Burnouf et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

64782

w^*; TI{TI}tau^KO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

dTau KO

(Goodman et al., 2024, Zerva et al., 2024)

dTau^KO

(Asadzadeh et al., 2022, Cassar et al., 2020)

dtau^KO

(Hoxha et al., 2024, Barber et al., 2017)

tau KO

(Gorsky et al., 2017, Burnouf et al., 2016)

tau-KO

(Shah et al., 2021)

tau^KO

(Hahn et al., 2021, Wolterhoff et al., 2020, Papanikolopoulou et al., 2019)

tauΔex6-14

(Goodman et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (15)

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