FlyBase Allele Report: Dmel\msps[A]

General Information

Symbol

Dmel\msps^A

Species

D. melanogaster

Name

FlyBase ID

FBal0369105

Feature type

allele

Associated gene

Dmel\msps

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Hahn et al., 2021)

Mutagen

Progenitor genotype

Cytology

Description

Small deletion causing a premature stop codon after 370 amino acids.

(Hahn et al., 2021)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:16,053,410..16,053,429 [+]

Comment:

msps[A] is a deletion of nucleatoides 3958-3977 of the Msps genomic sequence (GB:AJ249115). This results in a frameshift and premature translation termination.

(Ohkura, 2021.8.18)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | embryonic stage

(Hahn et al., 2021)

decreased size | larval stage (with msps¹⁴⁶)

(Hahn et al., 2021)

Phenotype Manifest In

axon | embryonic stage

(Hahn et al., 2021)

axon | larval stage (with msps¹⁴⁶)

(Hahn et al., 2021)

axon microtubule bundle | embryonic stage

(Hahn et al., 2021)

axon microtubule bundle | larval stage (with msps¹⁴⁶)

(Hahn et al., 2021)

microtubule plus-end | embryonic stage

(Hahn et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Eb1⁰⁴⁵²⁴, msps^A has decreased size | embryonic stage phenotype

(Hahn et al., 2021)

msps^A, tau^KO has decreased size | embryonic stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A has decreased size | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has decreased size | larval stage phenotype

(Hahn et al., 2021)

Phenotype Manifest In

Suppressed by

Statement

Reference

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype, suppressible by shot^LA.UAS.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

NOT suppressed by

Statement

Reference

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype, non-suppressible by shot^{RE-ΔABD.UAS.GFP}/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype, non-suppressible by shot^{RE-3MtLSmut.UAS.GFP}/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

msps¹⁴⁶/msps^A has microtubule plus-end | embryonic stage phenotype, non-suppressible by Eb1^UAS.cKa.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

msps¹⁴⁶/msps^A has axon | embryonic stage phenotype, non-suppressible by Eb1^UAS.cKa.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

msps¹⁴⁶/msps^A has axon microtubule bundle | embryonic stage phenotype, non-suppressible by Eb1^UAS.cKa.GFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Other

Statement

Reference

Eb1⁰⁴⁵²⁴, msps^A has axon | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has microtubule plus-end | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A has axon | embryonic stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A has axon microtubule bundle | embryonic stage phenotype

(Hahn et al., 2021)

msps^A, tau^KO has axon | embryonic stage phenotype

(Hahn et al., 2021)

msps^A, tau^KO has axon microtubule bundle | embryonic stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A has axon microtubule bundle | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A has microtubule plus-end | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon | larval stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has medulla | adult stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon | adult stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has axon microtubule bundle | adult stage phenotype

(Hahn et al., 2021)

Eb1⁰⁴⁵²⁴, msps^A, tau^KO has microtubule plus-end | embryonic stage phenotype

(Hahn et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

msps¹⁴⁶/msps^A is rescued by msps^{ΔCterm.UAS.EGFP}/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

msps¹⁴⁶/msps^A is rescued by msps^UAS.EGFP/Scer\GAL4^elav.PLu

(Hahn et al., 2021)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

msps^A

(Hahn et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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