FlyBase Allele Report: Dmel\mei-41[HMS02331]

General Information

Symbol

Dmel\mei-41^HMS02331

Species

D. melanogaster

Name

FlyBase ID

FBal0279330

Feature type

allele

Associated gene

Dmel\mei-41

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02331}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02331}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02331

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryo | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

female germline stem cell, with Scer\GAL4^nanos.PG

(Taslim et al., 2023)

midgut | conditional, with Scer\GAL4^esg.PU, Scer\GAL4^mex1.PU

(Geng et al., 2025)

primordial germ cell | embryonic stage, with Scer\GAL4^{VP16.nanos.UTR}

(Tarayrah-Ibraheim et al., 2021)

Detailed Description

Statement

Reference

Females heterozygous for mei-41^HMS02331 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to mei-41^HMS02331 males results in: 26% hatching; egg/embryonic phenotype: "dorsal closure defects, variable"; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^nanos.PU/mei-41^HMS02331 is an enhancer of decreased cell number | adult stage | female | temperature conditional phenotype of Crei\I-CreI^hs.PR

(Ma et al., 2016)

NOT Suppressor of

Statement

Reference

mei-41^HMS02331, Scer\GAL4^nanos.PU is a non-suppressor of decreased cell number | spermatogenesis | progressive phenotype of Rtel1^HMS00770, Scer\GAL4^nanos.PU

(Yang et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^nanos.PU/mei-41^HMS02331 is an enhancer of female germline stem cell | adult stage | temperature conditional phenotype of Crei\I-CreI^hs.PR

(Ma et al., 2016)

NOT Suppressor of

Statement

Reference

mei-41^HMS02331, Scer\GAL4^nanos.PU is a non-suppressor of male germline stem cell | adult stage | decreased number phenotype of Rtel1^HMS00770, Scer\GAL4^nanos.PU

(Yang et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The loss of germline stem cells (GSCs) observed upon heat-shock induced expression of Crei\I-CreI^hs.PR (to introduce DNA damage) is further exacerbated by expression of mei-41^HMS02331 under the Scer\GAL4^nos.PU driver.

(Ma et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

41934

y¹ v¹; P{TRiP.HMS02331}attP40

NIG-Fly

HMS02331