FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ptcB.2.13
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General Information
Symbol
Dmel\ptcB.2.13
Species
D. melanogaster
Name
FlyBase ID
FBal0280220
Feature type
allele
Associated gene
Dmel\ptc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kagey et al., 2012)
Progenitor genotype
Cytology
Description

Amino acid replacement: W173R.

(Moore et al., 2022)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,660,339..8,660,339 [+]
Nucleotide change:

T8660339A

Amino acid change:

W173R | ptc-PA

Reported amino acid change:

W173R

(Moore et al., 2022)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When homozygous clones are induced using the eyFLP system, the resulting adult eyes are irregular and are composed entirely of wild-type tissue.

      (Kagey et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Dark82, ptcB.2.13 has wing disc | somatic clone phenotype, suppressible by +/Df(3L)mir-banΔ1

      (Kagey et al., 2012)
      Other
      Statement
      Reference

      Dark82, ptcB.2.13 has wing disc | somatic clone phenotype

      (Kagey et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When Ark82 ptcB.2.13 double mutant clones are induced in the eye disc using the eyFLP system, the resulting adult eyes show strong overgrowth of wild-type tissue relative to mutant tissue.

      Ark82 ptcB.2.13 double mutant clones induced in the larval wing disc result in dramatically enlarged third larval instar wing discs (due to enlargement of the anterior domain) and pupal lethality. If the wing disc is made entirely mutant for Ark82 ptcB.2.13 (by using a cell-lethal Minute allele to eliminate the tissue that is not doubly mutant for Ark82 ptcB.2.13) the wing disc size is reduced compared to Ark82 ptcB.2.13 mosaic wing discs.

      Ark82 ptcB.2.13 mosaic wing discs show elevated increased cell proliferation in both mutant cells and adjacent wild-type cells compared to wild-type controls.

      The wing disc overgrowth phenotype caused by Ark82 ptcB.2.13 double mutant clones is suppressed by Df(3L)banΔ1/+.

      (Kagey et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PtcB.2.13
      (Moore et al., 2022)
      ptcB.2.13
      (Kagey et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)