FlyBase Allele Report: Dmel\CrebB[UAS.b.cYa]

General Information

Symbol

Dmel\CrebB^UAS.b.cYa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Yin

FlyBase ID

FBal0280376

Feature type

allele

Associated gene

Dmel\CrebB

Associated Insertion(s)

Carried in Construct

P{UAS-CrebB-17A.Y}

Also Known As

UAS-CREB2-b, UAS-dCREB2b

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Iijima-Ando et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-CrebB-17A.Y}

Cytology

Description

UAS regulatory sequences drive expression of the b isoform of CrebB.

(Iijima-Ando et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

CrebB

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived, with Scer\GAL4^elav-C155

(Iijima-Ando et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies expressing CrebB-17A^{Scer\UAS.b.cYa} under the control of Scer\GAL4^elav-C155 have a significantly shortened lifespan compared to controls. Neurodegeneration is not prominent in the brains of these flies.

(Iijima-Ando et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

CrebB^UAS.b.cYa/Scer\GAL4^unspecified is a suppressor of abnormal neuroanatomy | larval stage phenotype of SERCA^Kum170, comt⁶

(Freeman et al., 2010)

CrebB^UAS.b.cYa/Scer\GAL4^unspecified is a suppressor of abnormal neurophysiology | larval stage phenotype of SERCA^Kum170, comt⁶

(Freeman et al., 2010)

CrebB^UAS.b.cYa, Scer\GAL4^unspecified is a suppressor of abnormal neuroanatomy | larval stage phenotype of Ras85D^V12.S35.UAS, Scer\GAL4^unspecified

(Freeman et al., 2010)

CrebB^UAS.b.cYa, Scer\GAL4^unspecified is a suppressor of abnormal neurophysiology | larval stage phenotype of Ras85D^V12.S35.UAS, Scer\GAL4^unspecified

(Freeman et al., 2010)

NOT Suppressor of

Statement

Reference

CrebB^UAS.b.cYa, Scer\GAL4^ey.3.5.Exel is a non-suppressor of visible phenotype of Ras85D^V12.S35.UAS, Scer\GAL4^ey.3.5.Exel

(Freeman et al., 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

CrebB^UAS.b.cYa/Scer\GAL4^unspecified is a suppressor of neuromuscular junction | larval stage phenotype of SERCA^Kum170, comt⁶

(Freeman et al., 2010)

CrebB^UAS.b.cYa, Scer\GAL4^unspecified is a suppressor of embryonic/larval neuromuscular junction | larval stage phenotype of Ras85D^V12.S35.UAS, Scer\GAL4^unspecified

(Freeman et al., 2010)

NOT Suppressor of

Statement

Reference

CrebB^UAS.b.cYa, Scer\GAL4^ey.3.5.Exel is a non-suppressor of eye phenotype of Ras85D^V12.S35.UAS, Scer\GAL4^ey.3.5.Exel

(Freeman et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of CrebB-17A^{Scer\UAS.b.cYa} in motor neurons under the control of Scer\GAL4^unspecified suppresses the increased synaptic growth and transmitter release observed at the neuromuscular junction in comt⁶ Ca-P60A^Kum170 larvae.

Co-expression of CrebB-17A^{Scer\UAS.b.cYa} suppresses the increased synaptic growth and transmitter release observed at the neuromuscular junction in larvae expressing Ras85D^{V12.S35.Scer\UAS} in the motor neurons under the control of Scer\GAL4^unspecified.

Co-expression of CrebB-17A^{Scer\UAS.b.cYa} does not suppress the eye tumour phenotype caused by expression of Ras85D^{V12.S35.Scer\UAS} under the control of Scer\GAL4^ey.3.5.Exel.

(Freeman et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CrebB-17A^{Scer\UAS.b.cYa}

CrebB^{Scer\UAS.b.cYa}

CrebB^UAS.b.cYa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Yin

Secondary FlyBase IDs

References (6)

Report Sections

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