FlyBase Allele Report: Dmel\PlexA[MB09499]

General Information

Symbol

Dmel\PlexA^MB09499

Species

D. melanogaster

Name

FlyBase ID

FBal0280754

Feature type

allele

Associated gene

Dmel\PlexA

Associated Insertion(s)

Mi{ET1}PlexA^MB09499

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

Mi{ET1}PlexA^MB09499

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Mi{ET1}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

4:1,016,996..1,016,996 [-]

(Bustillo et al., 2024, Hernandez-Fleming et al., 2017, Jeong et al., 2012)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Charcot-Marie-Tooth disease type 2D

modeled by GlyRS^P234KY-2.UAS

(Grice et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | P-stage

(Bustillo et al., 2024)

abnormal size | P-stage

(Bustillo et al., 2024)

lethal

(Bustillo et al., 2024)

lethal (with Df(4)8-M91)

(Weasner et al., 2025)

lethal (with Df(4)8-M318)

(Weasner et al., 2025)

lethal (with Df(4)sc^H)

(Weasner et al., 2025)

Phenotype Manifest In

medulla | P-stage

(Bustillo et al., 2024)

neurite | P-stage

(Bustillo et al., 2024)

photoreceptor cell R7 | P-stage

(Bustillo et al., 2024)

photoreceptor cell R8 | P-stage

(Bustillo et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

PlexA^MB09499/plexA[+] is a suppressor | partially of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^elav.PLu, Sema1a^Fc.mICD.UAS, pbl^UAS.N.Tag:HA

(Jeong et al., 2012)

PlexA^MB09499/plexA[+] is a suppressor of abnormal neuroanatomy | embryonic stage phenotype of Scer\GAL4^elav.PLu, Sema1a^UAS.cJa, pbl^UAS.N.Tag:HA

(Jeong et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

PlexA^MB09499/plexA[+] is a suppressor of larval central nervous system | embryonic stage phenotype of Scer\GAL4^elav.PLu, Sema1a^Fc.mICD.UAS, pbl^UAS.N.Tag:HA

(Jeong et al., 2012)

PlexA^MB09499/plexA[+] is a suppressor of lateral longitudinal fascicle phenotype of Scer\GAL4^elav.PLu, Sema1a^UAS.cJa, pbl^UAS.N.Tag:HA

(Jeong et al., 2012)

NOT Suppressor of

Statement

Reference

PlexA^MB09499/plexA[+] is a non-suppressor of larval intersegmental nerve branch ISNb of A1-7 phenotype of Scer\GAL4^elav.PLu, Sema1a^Fc.mICD.UAS, pbl^UAS.N.Tag:HA

(Jeong et al., 2012)

PlexA^MB09499/plexA[+] is a non-suppressor of larval intersegmental nerve branch ISNb of A1-7 phenotype of Scer\GAL4^elav.PLu, Sema1a^UAS.cJa, pbl^UAS.N.Tag:HA

(Jeong et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

plexA^MB09499/+ strongly suppresses the lateral longitudinal central nervous system defects seen in embryos co-expressing Sema-1a^Scer\UAS.cJa and pbl^{Scer\UAS.N.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu, while the ISNb defects are not suppressed.

plexA^MB09499/+ significantly suppresses the central nervous system defects seen in embryos co-expressing Sema-1a^{mICD.Scer\UAS.T:Hsap\Fc-IgG} and pbl^{Scer\UAS.N.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu, while the ISNb defects are not suppressed.

(Jeong et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (7)

Bloomington

606776