FB2026_02 , released June 18, 2026
Allele: Dmel\Apc2EGFP,Tag:PM(c-Ha-Ras)
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General Information
Symbol
Dmel\Apc2EGFP,Tag:PM(c-Ha-Ras)
Species
D. melanogaster
Name
FlyBase ID
FBal0280777
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
M{Apc2-EGFP.HCAAX}
Key Links
Transgenic product class
wild_type
(Roberts et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Roberts et al., 2012)
Mutagen
in vitro construct
(Roberts et al., 2012)
Progenitor genotype
Carried in construct
M{Apc2-EGFP.HCAAX}
Cytology
Description

The endogenous Apc2 promoter drives expression of full-length, wild-type Apc2 which is tagged at the C-terminal end with a membrane targeting signal (Tag:PM(c-Ha-Ras)) and at the N-terminal end with EGFP.

(Roberts et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
Apc2
Encoded product / tool
Apc2
Tagged with
EGFP
Tag:PM(c-Ha-Ras)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The cuticle defects of embryos derived from Apc2g10 ApcQ8 males crossed to females containing double homozygous germline clones are strongly rescued by expression of Apc2T:Avic\GFP-EGFP,T:Mmmm\c-Ha-Ras. The embryonic lethality is partially rescued (41% lethality is seen).

      (Roberts et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Apc2EGFP,Tag:PM(c-Ha-Ras) partially rescues Apc2g10

      (Roberts et al., 2012)
      Comments

      Apc2T:Avic\GFP-EGFP,T:Mmmm\c-Ha-Ras rescues the cuticle defects of embryos lacking both maternal and zygotic Apc2[+] function (homozygous Apc2g10 embryos derived from Apc2g10 females). The embryonic lethality of these Apc2 mutants is partially rescued (34% embryonic lethality is seen), and viable adults are obtained.

      (Roberts et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Apc2EGFP,Tag:PM(c-Ha-Ras)
      Apc2T:Avic\GFP-EGFP,T:Mmmm\c-Ha-Ras
      Name Synonyms
      Secondary FlyBase IDs
        References (1)