FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\staiRNAi.UAS.WIZ
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General Information
Symbol
Dmel\staiRNAi.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0280811
Feature type
allele
Associated gene
Dmel\stai
Associated Insertion(s)
Carried in Construct
P{UAS-stai.RNAi.WIZ}
Key Links
Transgenic product class
RNAi_reagent
(Borghese et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Borghese et al., 2006)
Mutagen
in vitro construct
(Borghese et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-stai.RNAi.WIZ}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 500bp of the stai coding region which is common to all three isoforms.

(Borghese et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
stai
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of staidsRNA.Scer\UAS.WIZ under the control of pan-glial Scer\GAL4repo does not reduce bouton number at muscle 4 neuromuscular junctions and results in no observable footprints at either muscle 4 or muscle 6/7 neuromuscular junctions.

      Neuron-specific expression of staidsRNA.Scer\UAS.WIZ under the control of Scer\GAL4elav.Switch.PO results in neuromuscular junctions that are significantly smaller than in wild-type and a 43% reduction in bouton number. Synaptic retractions are observed in ~40% of muscle 6/7 neuromuscular junctions in segment 4.

      Muscle-specific expression of staidsRNA.Scer\UAS.WIZ, under the control of Scer\GAL4how-24B does not affect bouton number at muscle 4 neuromuscular junctions and does not result in synaptic retraction at muscle 4 or 6/7 neuromuscular junctions.

      (Graf et al., 2011)

      Females expressing staidsRNA.Scer\UAS.WIZ under the control of Scer\GAL4slbo.2.6 in a staiexC/Df(2L)staiL27 background show a delay in border cell migration.

      (Borghese et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The delay in border cell migration seen in females expressing staidsRNA.Scer\UAS.WIZ under the control of Scer\GAL4slbo.2.6 in a staiexC/Df(2L)staiL27 background are rescued by co-expression of staiScer\UAS.cBa.

      (Borghese et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      staiRNAi.UAS.WIZ
      staidsRNA.Scer\UAS.WIZ
      staidsRNA.UAS.WIZ
      Name Synonyms
      Secondary FlyBase IDs
        References (3)