Expression of kuk^{Scer\UAS.P\T.cBa} in the longitudinal muscle cells of one week old flies under the control of Scer\GAL4^{Mhc.Switch.PO} (induced by feeding RU486 to flies at the adult stages) results in a significant increase in nuclear perimeter and wrinkled, lobulated nuclei. Analysis using electron microscopy shows that these flies display nuclear phenotypes usually only observed during aging. Loss of peripheral heterochromatin, separation of inner and outer nuclear membrane, accumulation of ring like structures and a strong increase of dark material in the nucleoplasm are all observed. No changes in nuclear morphology are seen when kuk^{Scer\UAS.P\T.cBa} is expressed in the fat body under the control of Scer\GAL4^Switch1.106.

Expression of kuk^{Scer\UAS.P\T.cBa} in adult muscle cells under the control of Scer\GAL4^{Mhc.Switch.PO} (induced by feeding RU486 to flies at the adult stages) results in a 60% reduction in mean lifespan compared to controls. While the mortality rate is similar to controls, the time of onset differs. Expression of kuk^{Scer\UAS.P\T.cBa} in either the abdominal fat body or the nervous system under the control of Scer\GAL4^Switch1.106 and Scer\GAL4^{elav.Switch.PO} respectively has no effect on lifespan.

The nuclei of fat body cells expressing kuk^{Scer\UAS.P\T.cBa} under the control of Scer\GAL4^Switch1.106 (induced by feeding RU486 to flies at the adult stages) are similar in size to controls. A small number of neurons show an increase in nuclear size when kuk^{Scer\UAS.P\T.cBa} is expressed under the control of Scer\GAL4^{elav.Switch.PO}.

Flies expressing kuk^{Scer\UAS.P\T.cBa} under the control of Scer\GAL4^{Mhc.Switch.PO} (induced by feeding RU486 to flies at the adult stages) show an early decline in climbing ability compared to controls. No climbing defects are seen when kuk^{Scer\UAS.P\T.cBa} is expressed under the control of Scer\GAL4^Switch1.106.