FlyBase Allele Report: Dmel\HtrA2[UAS.cPa]

General Information

Symbol

Dmel\HtrA2^UAS.cPa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Park

FlyBase ID

FBal0281751

Feature type

allele

Associated gene

Dmel\HtrA2

Associated Insertion(s)

Carried in Construct

P{UAS-HtrA2.P}

Key Links

Transgenic product class

cDNA

(Park et al., 2006)

wild_type

(Park et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Park et al., 2006)

wild_type

(Park et al., 2006)

Mutagen

in vitro construct

(Park et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-HtrA2.P}

Cytology

Description

UAS regulatory sequences drive expression of a HtrA2 cDNA.

(Park et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

HtrA2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Detailed Description

Statement

Reference

Expression of HtrA2^Scer\UAS.cPa under the control of Scer\GAL4^GMR.PF does not cause disorganisation of the eye surface, but does result in a loss of pigmentation.

(Whitworth et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Pink1^B9

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

Enhancer of

Statement

Reference

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, rho-7^UAS.cWa

(Whitworth et al., 2008)

Other

Statement

Reference

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype

(Whitworth et al., 2008)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has eye | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Pink1^B9

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

Enhancer of

Statement

Reference

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF is an enhancer of eye | adult stage phenotype of Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, rho-7^UAS.cWa

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF is an enhancer of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, rho-7^UAS.cWa

(Whitworth et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of HtrA2^Scer\UAS.cPa enhances the disorganised eye phenotype seen when Pink1^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PF, resulting in a significant reduction in eye size. This phenotype is not suppressed in a park²⁵ mutant background.

Pink1^B9 does not suppress the eye pigmentation loss seen in flies expressing HtrA2^Scer\UAS.cPa under the control of Scer\GAL4^GMR.PF.

No eye phenotypes are observed when park^Scer\UAS.cGa and HtrA2^Scer\UAS.cPa are co-expressed under the control of Scer\GAL4^GMR.PF.

Expression of HtrA2^Scer\UAS.cPa enhances the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF, resulting in severe loss of eye tissue. This phenotype is not suppressed by park²⁵.

(Whitworth et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

HtrA2^Scer\UAS.cPa

HtrA2^UAS.cPa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Park

Secondary FlyBase IDs

References (2)

Report Sections

Open Close