FlyBase Allele Report: Dmel\rho-7[UAS.cWa]

General Information

Symbol

Dmel\rho-7^UAS.cWa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Whitworth

FlyBase ID

FBal0282033

Feature type

allele

Associated gene

Dmel\rho-7

Associated Insertion(s)

Carried in Construct

P{UAS-rho-7.W}

Key Links

Transgenic product class

wild_type

(Whitworth et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Whitworth et al., 2008)

Mutagen

in vitro construct

(Whitworth et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-rho-7.W}

Cytology

Description

UAS regulatory sequences drive expression of rho-7.

(Whitworth et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

rho-7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Detailed Description

Statement

Reference

Expression of rho-7^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PF results in a rough eye phenotype, with widespread loss of bristles.

(Whitworth et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, enhanceable by Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, enhanceable by park^UAS.cGa/Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, enhanceable by HtrA2^UAS.cPa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, suppressible | partially by Pink1^B9

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, suppressible | partially by park²⁵

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, suppressible | partially by HtrA2^Δ1

(Whitworth et al., 2008)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, park^UAS.cGa, rho-7^UAS.cWa has visible phenotype, non-suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF, rho-7^UAS.cWa has visible phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, enhanceable by Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, enhanceable by Pink1^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, enhanceable by park^UAS.cGa/Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, enhanceable by park^UAS.cGa/Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, enhanceable by HtrA2^UAS.cPa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, enhanceable by HtrA2^UAS.cPa, Scer\GAL4^GMR.PF

(Whitworth et al., 2008)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, suppressible | partially by HtrA2^Δ1

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, suppressible | partially by HtrA2^Δ1

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, suppressible | partially by Pink1^B9

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, suppressible | partially by Pink1^B9

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, suppressible | partially by park²⁵

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, suppressible | partially by park²⁵

(Whitworth et al., 2008)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, park^UAS.cGa, rho-7^UAS.cWa has eye phenotype, non-suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

Scer\GAL4^GMR.PF, park^UAS.cGa, rho-7^UAS.cWa has interommatidial bristle phenotype, non-suppressible by HtrA2^Δ1

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF, rho-7^UAS.cWa has eye phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

HtrA2^UAS.cPa, Scer\GAL4^GMR.PF, rho-7^UAS.cWa has interommatidial bristle phenotype, non-suppressible by park²⁵

(Whitworth et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Pink1^{Scer\UAS.T:Ivir\HA1} enhances the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF. The eye is much smaller with distorted morphology and complete loss of bristles. A less severe rough eye phenotype is seen when Pink1^{Scer\UAS.T:Ivir\HA1} is co-expressed with rho-7^SA.Scer\UAS.

Pink1^B9 partially suppresses the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF. The normal abundance of interommatidial bristles is restored.

Expression of park^Scer\UAS.cGa enhances the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF, resulting in severe loss of eye tissue. This phenotype is not suppressed by HtrA2^Δ1.

Expression of HtrA2^Scer\UAS.cPa enhances the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF, resulting in severe loss of eye tissue. This phenotype is not suppressed by park²⁵.

park²⁵ partially suppresses the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF.

HtrA2^Δ1 partially suppresses the rough eye phenotype seen when rho-7^Scer\UAS.cWa is expressed under the control of Scer\GAL4^GMR.PF.

(Whitworth et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

rho-7^Scer\UAS.cWa

rho-7^UAS.cWa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Whitworth

Secondary FlyBase IDs

References (2)

Report Sections

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